Cell-free methylation markers with diagnostic and prognostic potential in hepatocellular carcinoma

Chang Yi Lu, Shih Ya Chen, Hui Ling Peng, Pu Yeh Kan, Wan Chi Chang, Chia Jui Yen

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Hepatocellular carcinoma (HCC) is a highly malignant tumor with poor prognosis and high mortality. There is a dearth of effective early diagnostic tools, so liver resection surgery and liver transplantation are the only effective medical treatments. The most commonly used marker for HCC detection is serum alpha fetoprotein (AFP), which has low sensitivity and specificity. Because aberrant DNA methylation of genes and miRNAs occurs early in most cancers, we explored whether circulating methylation markers could be promising clinical tools for HCC diagnosis. Using a whole-genome approach, we identified many hyper-methylated miRNAs in HCC. Furthermore, three abnormally methylated genes and one miRNA were combined to establish a methylation predictive model and tested for its diagnostic and prognostic potential in HCC. Using plasma samples, the predictive model exhibited high sensitivity and specificity (> 80%) for HBV-related HCC. Most importantly, nearly 75% of patients who could not be diagnosed with AFP at 20 ng/mL were detected by this model. Further, the predictive model exhibited an exceedingly high ability to predict 5-year overall survival in HCC patients. These data demonstrate the high diagnostic and prognostic potential of methylation markers in the plasma of HCC patients.

原文English
頁(從 - 到)6406-6418
頁數13
期刊Oncotarget
8
發行號4
DOIs
出版狀態Published - 2017

All Science Journal Classification (ASJC) codes

  • Oncology

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