Cell migration after synovium graft interposition at tendon repair site

Masanori Hayashi, Chunfeng Zhao, Kai Nan An, Peter C. Amadio

研究成果: Review article同行評審

2 引文 斯高帕斯(Scopus)


Background: We have recently reported that interpositional synovium grafts from tendon sheath have a potential to accelerate tendon healing when implanted at the repair site. The purpose of this study was to investigate the effect of orientation of the synovium after synovium graft transplantation, by comparing the ability of cells from the visceral and parietal surfaces to migrate into the tendon in a canine tissue culture model. Methods: The synovium graft was placed within a complete tendon laceration, with either the visceral or parietal surface facing the proximal end of the lacerated tendon. The number of migrating cells was quantified by a cell migration assay. Qualitative immunohistochemistry and confocal laser microscopy were also used at day 10. Results: Many labeled synovial cells were observed within the tendon to which the visceral surface of the synovium graft was facing. Migrated cells were also observed on the parietal side, but there were fewer cells compared to visceral surface cells. Migrating cells all expressed α-smooth muscle actin. Conclusion: We found that graft orientation affected cell migration. Whether this finding has clinical significance awaits in vivo study.

頁(從 - 到)374-379
出版狀態Published - 2012 12月

All Science Journal Classification (ASJC) codes

  • 手術
  • 骨科和運動醫學


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