Cell patterning using magnetic concentric rectangular thin films for biochip application

In this report, magnetic cell patterning is demonstrated through controlling the micromagnetic states in microstructured concentric rectangular ferromagnetic thin films. The number of magnetic nanoparticles entered the cells via endocytosis can be determined by magnetophoresis experiment. In concentric rectangular magnetic films, the effects of cell patterning differ from magnetic films at as-deposited state and at remnant states after applying field. Remnant states of concentric rectangular are proposed for cell patterning. Living cells can be arranged at specific diagonal direction in sequence by selectively changing the magnetic field directions.