Cell therapy in dermatology

Gabriela Petrof, Alya Abdul-Wahab, John A. McGrath

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)

摘要

Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in derma- tology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.

原文English
期刊Cold Spring Harbor perspectives in medicine
4
發行號6
DOIs
出版狀態Published - 2014

All Science Journal Classification (ASJC) codes

  • 一般生物化學,遺傳學和分子生物學

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