Cellular-level near-wall unsteadiness of high-hematocrit erythrocyte flow using confocal μpIV

Michael J. Patrick, Chia Yuan Chen, David H. Frakes, Onur Dur, Kerem Pekkan

研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)

摘要

In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention. Unsteadiness is reported and quantified for the first time in the literature using a combination of fluorescent dye labeling, time-resolved scanning confocal microscopy, and micro-particle image velocimetry (μPIV). The near-wall red blood cell (RBC) motion of physiologic high-hematocrit blood in a rectangular microchannel was investigated under pressure-driven flow. Intermittent flow was associated with (1) the stretching of RBCs as they passed through RBC clusters with twisting motions; (2) external flow through local obstacles; and (3) transitionary rouleaux formations. Velocity profiles are presented for these cases. Unsteady flow clustered in local regions. Extra-cellular fluid flow generated by individual RBCs was examined using submicron fluorescent microspheres. The capabilities of confocal μPIV post-processing were verified using synthetic raw PIV data for validation. Cellular interactions and oscillating velocity profiles are presented, and 3D data are made available for computational model validation.

原文English
頁(從 - 到)887-904
頁數18
期刊Experiments in Fluids
50
發行號4
DOIs
出版狀態Published - 2011 四月

All Science Journal Classification (ASJC) codes

  • 計算力學
  • 材料力學
  • 物理與天文學 (全部)
  • 流體流動和轉移過程

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