TY - JOUR
T1 - Central Channelopathies in Obesity
AU - Li, Athena Hsu
AU - Kuo, Yi Ying
AU - Yang, Shi Bing
AU - Chen, Pei Chun
N1 - Publisher Copyright:
© 2024 Journal of Physiological Investigation.
PY - 2024
Y1 - 2024
N2 - As obesity has raised heightening awareness, researchers have attempted to identify potential targets that can be treated for therapeutic intervention. Focusing on the central nervous system (CNS), the key organ in maintaining energy balance, a plethora of ion channels that are expressed in the CNS have been inspected and determined through manipulation in different hypothalamic neural subpopulations for their roles in fine-tuning neuronal activity on energy state alterations, possibly acting as metabolic sensors. However, a remaining gap persists between human clinical investigations and mouse studies. Despite having delineated the pathways and mechanisms of how the mouse study-identified ion channels modulate energy homeostasis, only a few targets overlap with the obesity-related risk genes extracted from human genome-wide association studies. Here, we present the most recently discovered CNS-specific metabolism-correlated ion channels using reverse and forward genetics approaches in mice and humans, respectively, in the hope of illuminating the prospects for future therapeutic development.
AB - As obesity has raised heightening awareness, researchers have attempted to identify potential targets that can be treated for therapeutic intervention. Focusing on the central nervous system (CNS), the key organ in maintaining energy balance, a plethora of ion channels that are expressed in the CNS have been inspected and determined through manipulation in different hypothalamic neural subpopulations for their roles in fine-tuning neuronal activity on energy state alterations, possibly acting as metabolic sensors. However, a remaining gap persists between human clinical investigations and mouse studies. Despite having delineated the pathways and mechanisms of how the mouse study-identified ion channels modulate energy homeostasis, only a few targets overlap with the obesity-related risk genes extracted from human genome-wide association studies. Here, we present the most recently discovered CNS-specific metabolism-correlated ion channels using reverse and forward genetics approaches in mice and humans, respectively, in the hope of illuminating the prospects for future therapeutic development.
UR - http://www.scopus.com/inward/record.url?scp=85204797549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85204797549&partnerID=8YFLogxK
U2 - 10.4103/ejpi.EJPI-D-23-00029
DO - 10.4103/ejpi.EJPI-D-23-00029
M3 - Review article
AN - SCOPUS:85204797549
SN - 2950-6344
VL - 67
SP - 15
EP - 26
JO - Journal of Physiological Investigation
JF - Journal of Physiological Investigation
IS - 1
ER -