Central Channelopathies in Obesity

Athena Hsu Li, Yi Ying Kuo, Shi Bing Yang, Pei Chun Chen

研究成果: Review article同行評審

1 引文 斯高帕斯(Scopus)

摘要

As obesity has raised heightening awareness, researchers have attempted to identify potential targets that can be treated for therapeutic intervention. Focusing on the central nervous system (CNS), the key organ in maintaining energy balance, a plethora of ion channels that are expressed in the CNS have been inspected and determined through manipulation in different hypothalamic neural subpopulations for their roles in fine-tuning neuronal activity on energy state alterations, possibly acting as metabolic sensors. However, a remaining gap persists between human clinical investigations and mouse studies. Despite having delineated the pathways and mechanisms of how the mouse study-identified ion channels modulate energy homeostasis, only a few targets overlap with the obesity-related risk genes extracted from human genome-wide association studies. Here, we present the most recently discovered CNS-specific metabolism-correlated ion channels using reverse and forward genetics approaches in mice and humans, respectively, in the hope of illuminating the prospects for future therapeutic development.

原文English
頁(從 - 到)15-26
頁數12
期刊Journal of Physiological Investigation
67
發行號1
DOIs
出版狀態Published - 2024

All Science Journal Classification (ASJC) codes

  • 生理學
  • 生理學(醫學)

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