Central nervous system candidiasis in very low-birth-weight premature neonates and infants: US characteristics and histopathologic and MR imaging correlates in five patients

Chao Ching Huang, Cheng Yu Chen, Hsiao Bai Yang, Shih Min Wang, Ying Chao Chang, Ching Chuan Liu

研究成果: Article

22 引文 (Scopus)

摘要

PURPOSE: To analyze the high-resolution (ie, 5.0- or 7.5-MHz) ultrasonographic (US) imaging characteristics of central nervous system (CNS) candidiasis and their histopathologic and magnetic resonance (MR) imaging correlates in very low-birth-weight (VLBW) premature neonates and infants with systemic candidiasis. MATERIALS AND METHODS: The US images obtained in one VLBW neonate (age, 24 days; weight, 846 g) and four VLBW infants (age range, 36-161 days; weight range, 800-1,360 g) with proved CNS candidiasis complicating systemic candidiasis and the clinical (n = 5), histophatologic (n = 3), and MR imaging (n = 2) correlates were retrospectively reviewed. RESULTS: The cranial US findings consisted of parenchymal abnormalities in four and ventricular lesions in three patients. The most common findings were multiple echogenic, rimlike microabscesses (four patients) scattered in the subcortical, periventricular, and basal ganglial areas. Confluent macroabscess formation, seen as echogenic masslike lesions with hypoechoic centers in the periventricular regions and/or thalami, was noted on the US images obtained in two patients. The ventricles showed dilatation in two, increased ependymal echogenicity in three, the presence of intraventricular echogenic septa in two, and a lumpy choroid plexus or the presence of debris in two patients. US findings correlated well with MR imaging and autopsy findings. The histopathologic changes in the posterior fossa were well demonstrated on MR images but not demonstrated on 5.0- or 7.5-MHz US images. CONCLUSION: CNS candidiasis in VLBW neonates and infants has characteristic US features that may help in the early diagnosis of CNS involvement in systemic candidiasis.

原文English
頁(從 - 到)49-56
頁數8
期刊Radiology
209
發行號1
DOIs
出版狀態Published - 1998 十月

指紋

Very Low Birth Weight Infant
Candidiasis
Low Birth Weight Infant
Premature Infants
Central Nervous System
Magnetic Resonance Imaging
Newborn Infant
Weights and Measures
Choroid Plexus
Thalamus
Early Diagnosis
Dilatation
Autopsy
Magnetic Resonance Spectroscopy
Systemic candidiasis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

引用此文

@article{053bff10c30541388c6a506a79fc46b6,
title = "Central nervous system candidiasis in very low-birth-weight premature neonates and infants: US characteristics and histopathologic and MR imaging correlates in five patients",
abstract = "PURPOSE: To analyze the high-resolution (ie, 5.0- or 7.5-MHz) ultrasonographic (US) imaging characteristics of central nervous system (CNS) candidiasis and their histopathologic and magnetic resonance (MR) imaging correlates in very low-birth-weight (VLBW) premature neonates and infants with systemic candidiasis. MATERIALS AND METHODS: The US images obtained in one VLBW neonate (age, 24 days; weight, 846 g) and four VLBW infants (age range, 36-161 days; weight range, 800-1,360 g) with proved CNS candidiasis complicating systemic candidiasis and the clinical (n = 5), histophatologic (n = 3), and MR imaging (n = 2) correlates were retrospectively reviewed. RESULTS: The cranial US findings consisted of parenchymal abnormalities in four and ventricular lesions in three patients. The most common findings were multiple echogenic, rimlike microabscesses (four patients) scattered in the subcortical, periventricular, and basal ganglial areas. Confluent macroabscess formation, seen as echogenic masslike lesions with hypoechoic centers in the periventricular regions and/or thalami, was noted on the US images obtained in two patients. The ventricles showed dilatation in two, increased ependymal echogenicity in three, the presence of intraventricular echogenic septa in two, and a lumpy choroid plexus or the presence of debris in two patients. US findings correlated well with MR imaging and autopsy findings. The histopathologic changes in the posterior fossa were well demonstrated on MR images but not demonstrated on 5.0- or 7.5-MHz US images. CONCLUSION: CNS candidiasis in VLBW neonates and infants has characteristic US features that may help in the early diagnosis of CNS involvement in systemic candidiasis.",
author = "Huang, {Chao Ching} and Chen, {Cheng Yu} and Yang, {Hsiao Bai} and Wang, {Shih Min} and Chang, {Ying Chao} and Liu, {Ching Chuan}",
year = "1998",
month = "10",
doi = "10.1148/radiology.209.1.9769811",
language = "English",
volume = "209",
pages = "49--56",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Central nervous system candidiasis in very low-birth-weight premature neonates and infants

T2 - US characteristics and histopathologic and MR imaging correlates in five patients

AU - Huang, Chao Ching

AU - Chen, Cheng Yu

AU - Yang, Hsiao Bai

AU - Wang, Shih Min

AU - Chang, Ying Chao

AU - Liu, Ching Chuan

PY - 1998/10

Y1 - 1998/10

N2 - PURPOSE: To analyze the high-resolution (ie, 5.0- or 7.5-MHz) ultrasonographic (US) imaging characteristics of central nervous system (CNS) candidiasis and their histopathologic and magnetic resonance (MR) imaging correlates in very low-birth-weight (VLBW) premature neonates and infants with systemic candidiasis. MATERIALS AND METHODS: The US images obtained in one VLBW neonate (age, 24 days; weight, 846 g) and four VLBW infants (age range, 36-161 days; weight range, 800-1,360 g) with proved CNS candidiasis complicating systemic candidiasis and the clinical (n = 5), histophatologic (n = 3), and MR imaging (n = 2) correlates were retrospectively reviewed. RESULTS: The cranial US findings consisted of parenchymal abnormalities in four and ventricular lesions in three patients. The most common findings were multiple echogenic, rimlike microabscesses (four patients) scattered in the subcortical, periventricular, and basal ganglial areas. Confluent macroabscess formation, seen as echogenic masslike lesions with hypoechoic centers in the periventricular regions and/or thalami, was noted on the US images obtained in two patients. The ventricles showed dilatation in two, increased ependymal echogenicity in three, the presence of intraventricular echogenic septa in two, and a lumpy choroid plexus or the presence of debris in two patients. US findings correlated well with MR imaging and autopsy findings. The histopathologic changes in the posterior fossa were well demonstrated on MR images but not demonstrated on 5.0- or 7.5-MHz US images. CONCLUSION: CNS candidiasis in VLBW neonates and infants has characteristic US features that may help in the early diagnosis of CNS involvement in systemic candidiasis.

AB - PURPOSE: To analyze the high-resolution (ie, 5.0- or 7.5-MHz) ultrasonographic (US) imaging characteristics of central nervous system (CNS) candidiasis and their histopathologic and magnetic resonance (MR) imaging correlates in very low-birth-weight (VLBW) premature neonates and infants with systemic candidiasis. MATERIALS AND METHODS: The US images obtained in one VLBW neonate (age, 24 days; weight, 846 g) and four VLBW infants (age range, 36-161 days; weight range, 800-1,360 g) with proved CNS candidiasis complicating systemic candidiasis and the clinical (n = 5), histophatologic (n = 3), and MR imaging (n = 2) correlates were retrospectively reviewed. RESULTS: The cranial US findings consisted of parenchymal abnormalities in four and ventricular lesions in three patients. The most common findings were multiple echogenic, rimlike microabscesses (four patients) scattered in the subcortical, periventricular, and basal ganglial areas. Confluent macroabscess formation, seen as echogenic masslike lesions with hypoechoic centers in the periventricular regions and/or thalami, was noted on the US images obtained in two patients. The ventricles showed dilatation in two, increased ependymal echogenicity in three, the presence of intraventricular echogenic septa in two, and a lumpy choroid plexus or the presence of debris in two patients. US findings correlated well with MR imaging and autopsy findings. The histopathologic changes in the posterior fossa were well demonstrated on MR images but not demonstrated on 5.0- or 7.5-MHz US images. CONCLUSION: CNS candidiasis in VLBW neonates and infants has characteristic US features that may help in the early diagnosis of CNS involvement in systemic candidiasis.

UR - http://www.scopus.com/inward/record.url?scp=0031660674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031660674&partnerID=8YFLogxK

U2 - 10.1148/radiology.209.1.9769811

DO - 10.1148/radiology.209.1.9769811

M3 - Article

C2 - 9769811

AN - SCOPUS:0031660674

VL - 209

SP - 49

EP - 56

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -