Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity

研究成果: Article

73 引文 (Scopus)

摘要

Taiwan has experienced several outbreaks of enterovirus 71 (EV71) infections since 1998. This study examined the quantitative relationship between specific cytokines in the cerebrospinal fluid (CSF) and the severity of EV71 brain stem encephalitis (BE), and investigated whether the CSF cytokine response differed from that to uncomplicated echovirus meningitis (EM). The study included 57 children with EV71 BE, of whom 24 had isolated BE, 24 had autonomic nervous system (ANS) dysregulation, and nine had pulmonary oedema (PE), and 15 children with EM. All were confirmed by virus culture. Mean CSF glucose, total protein and lactate levels were increased significantly in association with the severity of EV71 BE. The mean CSF concentration of interleukin (IL)-1β in children with EV71 PE was significantly higher than in those with isolated BE. IL-6 and interferon (IFN)-γ levels were significantly higher for EV71 PE and ANS dysregulation than for isolated BE. In contrast, EM was associated with high levels of IL-1β and low levels of IFN-γ. Cytokines in the central nervous system, as well as in blood, appear to be involved in the pathogenesis of EV71 BE.

原文English
頁(從 - 到)677-682
頁數6
期刊Clinical Microbiology and Infection
13
發行號7
DOIs
出版狀態Published - 2007 一月 1

指紋

Echovirus Infections
Enterovirus
Encephalitis
Meningitis
Brain Stem
Cerebrospinal Fluid
Cytokines
Human Enterovirus B
Autonomic Nervous System
Interleukin-1
Interferons
Enterovirus Infections
Pulmonary Edema
Taiwan
Disease Outbreaks
Lactic Acid
Interleukin-6
Central Nervous System
Viruses
Glucose

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

引用此文

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title = "Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity",
abstract = "Taiwan has experienced several outbreaks of enterovirus 71 (EV71) infections since 1998. This study examined the quantitative relationship between specific cytokines in the cerebrospinal fluid (CSF) and the severity of EV71 brain stem encephalitis (BE), and investigated whether the CSF cytokine response differed from that to uncomplicated echovirus meningitis (EM). The study included 57 children with EV71 BE, of whom 24 had isolated BE, 24 had autonomic nervous system (ANS) dysregulation, and nine had pulmonary oedema (PE), and 15 children with EM. All were confirmed by virus culture. Mean CSF glucose, total protein and lactate levels were increased significantly in association with the severity of EV71 BE. The mean CSF concentration of interleukin (IL)-1β in children with EV71 PE was significantly higher than in those with isolated BE. IL-6 and interferon (IFN)-γ levels were significantly higher for EV71 PE and ANS dysregulation than for isolated BE. In contrast, EM was associated with high levels of IL-1β and low levels of IFN-γ. Cytokines in the central nervous system, as well as in blood, appear to be involved in the pathogenesis of EV71 BE.",
author = "Shih-Min Wang and Lei, {H. Y.} and Su, {L. Y.} and Jing-Ming Wu and Chun-Keung Yu and Jen-Ren Wang and Ching-Chuan Liu",
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AU - Yu, Chun-Keung

AU - Wang, Jen-Ren

AU - Liu, Ching-Chuan

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N2 - Taiwan has experienced several outbreaks of enterovirus 71 (EV71) infections since 1998. This study examined the quantitative relationship between specific cytokines in the cerebrospinal fluid (CSF) and the severity of EV71 brain stem encephalitis (BE), and investigated whether the CSF cytokine response differed from that to uncomplicated echovirus meningitis (EM). The study included 57 children with EV71 BE, of whom 24 had isolated BE, 24 had autonomic nervous system (ANS) dysregulation, and nine had pulmonary oedema (PE), and 15 children with EM. All were confirmed by virus culture. Mean CSF glucose, total protein and lactate levels were increased significantly in association with the severity of EV71 BE. The mean CSF concentration of interleukin (IL)-1β in children with EV71 PE was significantly higher than in those with isolated BE. IL-6 and interferon (IFN)-γ levels were significantly higher for EV71 PE and ANS dysregulation than for isolated BE. In contrast, EM was associated with high levels of IL-1β and low levels of IFN-γ. Cytokines in the central nervous system, as well as in blood, appear to be involved in the pathogenesis of EV71 BE.

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