Change of serotype pattern of Group D non-typhoidal Salmonella isolated from pediatric patients in southern Taiwan

Kuo Sheng Tsai, Yao Jong Yang, Shih Min Wang, Chien Shun Chiou, Ching Chuan Liu

研究成果: Article

10 引文 (Scopus)

摘要

Background and Purpose: Group D non-typhoidal Salmonella infection is increasing in Taiwan. This study aimed to investigate the changing serotypes and antibiotic resistance of childhood group D Salmonella infection. Methods: From 1998 through 2004, children (<16 years) infected with group D Salmonella were retrospectively reviewed. Demographic data, clinical and laboratory features, and risk factors of bacteremia were analyzed. Enrolled patients were classified as acute gastroenteritis with bacteremia (Group I) and acute gastroenteritis without bacteremia (Group II). The minimal inhibitory concentrations were determined by agar dilution method. Genotyping was performed by use of pulsed-field gel electrophoresis (PFGE). Results: Eighty one children (Group I, n = 15; Group II, n = 66) were enrolled with a mean (± standard deviation) age of 3.1 ± 2.6 years. Group I patients were younger and had a longer duration of fever prior to admission (≥5 days, 40% vs 9.2%; p=0.003) and total fever duration (8.3 vs 4.1 days, p<0.001) than Group II. Salmonella enterica serotype Enteritidis (80%) was the most common serotype, followed by Salmonella Panama (7%). The antibiotic resistance rates of S. Enteritidis were: tetracycline (36.5%), trimethoprim-sulfamethoxazole (25.4%), ampicillin (14.3%), and chloramphenicol (12.7%). S. Panama was associated with a higher rate of bacteremia. All strains were susceptible to quinolone and third-generation cephalosporins. PFGE study showed a single genotype of S. Enteritidis and diverse genotypes of S. Panama circulating in the area. Conclusions: S. Enteritidis was the predominant serotype of group D Salmonella that caused pediatric infection in southern Taiwan during the study period from 1998 to 2004. S. Panama is associated with higher rates of bacteremia and antimicrobial resistance.

原文English
頁(從 - 到)234-239
頁數6
期刊Journal of Microbiology, Immunology and Infection
40
發行號3
出版狀態Published - 2007 一月 1

指紋

Panama
Bacteremia
Taiwan
Salmonella
Pediatrics
Salmonella Infections
Pulsed Field Gel Electrophoresis
Gastroenteritis
Microbial Drug Resistance
Fever
Genotype
Salmonella enterica
Quinolones
Sulfamethoxazole Drug Combination Trimethoprim
Chloramphenicol
Cephalosporins
Ampicillin
Tetracycline
Agar
Demography

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

引用此文

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title = "Change of serotype pattern of Group D non-typhoidal Salmonella isolated from pediatric patients in southern Taiwan",
abstract = "Background and Purpose: Group D non-typhoidal Salmonella infection is increasing in Taiwan. This study aimed to investigate the changing serotypes and antibiotic resistance of childhood group D Salmonella infection. Methods: From 1998 through 2004, children (<16 years) infected with group D Salmonella were retrospectively reviewed. Demographic data, clinical and laboratory features, and risk factors of bacteremia were analyzed. Enrolled patients were classified as acute gastroenteritis with bacteremia (Group I) and acute gastroenteritis without bacteremia (Group II). The minimal inhibitory concentrations were determined by agar dilution method. Genotyping was performed by use of pulsed-field gel electrophoresis (PFGE). Results: Eighty one children (Group I, n = 15; Group II, n = 66) were enrolled with a mean (± standard deviation) age of 3.1 ± 2.6 years. Group I patients were younger and had a longer duration of fever prior to admission (≥5 days, 40{\%} vs 9.2{\%}; p=0.003) and total fever duration (8.3 vs 4.1 days, p<0.001) than Group II. Salmonella enterica serotype Enteritidis (80{\%}) was the most common serotype, followed by Salmonella Panama (7{\%}). The antibiotic resistance rates of S. Enteritidis were: tetracycline (36.5{\%}), trimethoprim-sulfamethoxazole (25.4{\%}), ampicillin (14.3{\%}), and chloramphenicol (12.7{\%}). S. Panama was associated with a higher rate of bacteremia. All strains were susceptible to quinolone and third-generation cephalosporins. PFGE study showed a single genotype of S. Enteritidis and diverse genotypes of S. Panama circulating in the area. Conclusions: S. Enteritidis was the predominant serotype of group D Salmonella that caused pediatric infection in southern Taiwan during the study period from 1998 to 2004. S. Panama is associated with higher rates of bacteremia and antimicrobial resistance.",
author = "Tsai, {Kuo Sheng} and Yang, {Yao Jong} and Wang, {Shih Min} and Chiou, {Chien Shun} and Liu, {Ching Chuan}",
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T1 - Change of serotype pattern of Group D non-typhoidal Salmonella isolated from pediatric patients in southern Taiwan

AU - Tsai, Kuo Sheng

AU - Yang, Yao Jong

AU - Wang, Shih Min

AU - Chiou, Chien Shun

AU - Liu, Ching Chuan

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background and Purpose: Group D non-typhoidal Salmonella infection is increasing in Taiwan. This study aimed to investigate the changing serotypes and antibiotic resistance of childhood group D Salmonella infection. Methods: From 1998 through 2004, children (<16 years) infected with group D Salmonella were retrospectively reviewed. Demographic data, clinical and laboratory features, and risk factors of bacteremia were analyzed. Enrolled patients were classified as acute gastroenteritis with bacteremia (Group I) and acute gastroenteritis without bacteremia (Group II). The minimal inhibitory concentrations were determined by agar dilution method. Genotyping was performed by use of pulsed-field gel electrophoresis (PFGE). Results: Eighty one children (Group I, n = 15; Group II, n = 66) were enrolled with a mean (± standard deviation) age of 3.1 ± 2.6 years. Group I patients were younger and had a longer duration of fever prior to admission (≥5 days, 40% vs 9.2%; p=0.003) and total fever duration (8.3 vs 4.1 days, p<0.001) than Group II. Salmonella enterica serotype Enteritidis (80%) was the most common serotype, followed by Salmonella Panama (7%). The antibiotic resistance rates of S. Enteritidis were: tetracycline (36.5%), trimethoprim-sulfamethoxazole (25.4%), ampicillin (14.3%), and chloramphenicol (12.7%). S. Panama was associated with a higher rate of bacteremia. All strains were susceptible to quinolone and third-generation cephalosporins. PFGE study showed a single genotype of S. Enteritidis and diverse genotypes of S. Panama circulating in the area. Conclusions: S. Enteritidis was the predominant serotype of group D Salmonella that caused pediatric infection in southern Taiwan during the study period from 1998 to 2004. S. Panama is associated with higher rates of bacteremia and antimicrobial resistance.

AB - Background and Purpose: Group D non-typhoidal Salmonella infection is increasing in Taiwan. This study aimed to investigate the changing serotypes and antibiotic resistance of childhood group D Salmonella infection. Methods: From 1998 through 2004, children (<16 years) infected with group D Salmonella were retrospectively reviewed. Demographic data, clinical and laboratory features, and risk factors of bacteremia were analyzed. Enrolled patients were classified as acute gastroenteritis with bacteremia (Group I) and acute gastroenteritis without bacteremia (Group II). The minimal inhibitory concentrations were determined by agar dilution method. Genotyping was performed by use of pulsed-field gel electrophoresis (PFGE). Results: Eighty one children (Group I, n = 15; Group II, n = 66) were enrolled with a mean (± standard deviation) age of 3.1 ± 2.6 years. Group I patients were younger and had a longer duration of fever prior to admission (≥5 days, 40% vs 9.2%; p=0.003) and total fever duration (8.3 vs 4.1 days, p<0.001) than Group II. Salmonella enterica serotype Enteritidis (80%) was the most common serotype, followed by Salmonella Panama (7%). The antibiotic resistance rates of S. Enteritidis were: tetracycline (36.5%), trimethoprim-sulfamethoxazole (25.4%), ampicillin (14.3%), and chloramphenicol (12.7%). S. Panama was associated with a higher rate of bacteremia. All strains were susceptible to quinolone and third-generation cephalosporins. PFGE study showed a single genotype of S. Enteritidis and diverse genotypes of S. Panama circulating in the area. Conclusions: S. Enteritidis was the predominant serotype of group D Salmonella that caused pediatric infection in southern Taiwan during the study period from 1998 to 2004. S. Panama is associated with higher rates of bacteremia and antimicrobial resistance.

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