TY - JOUR
T1 - Characterization of iron core-gold shell nanoparticles for anti-cancer treatments
T2 - Chemical and structural transformations during storage and use
AU - Wu, Ya Na
AU - Shieh, Dar Bin
AU - Yang, Li Xing
AU - Sheu, Hwo Shuenn
AU - Zheng, Rongkun
AU - Thordarson, Pall
AU - Chen, Dong Hwang
AU - Braet, Filip
N1 - Funding Information:
Author Contributions: Conceptualization, Y.W.,D.B., D.H. and F.B.; methodology, Y.W., L.Y., H.S. and R.Z.; validation, Y.W. and L.Y.; formal analysis, Y.W. and H.S.; investigation, Y.W., L.Y., H.S. and R.Z.; resources, D.B., P.T. and F.B.; writing—original draft preparation, Y.W.; writing—review and editing, P.T. and F.B.; visualization, Y.W.; supervision, F.B. and D.B..; project administration, Y.W.; funding acquisition, D.B., P.T. and F.B.” Funding: This research was funded by the Ministry of Science and Technology, Taiwan, (Grant No.: 107-2321-B-006-019-101-2120-M-006-008, 106-2627-M-006-001 and 104-2314-B-006-063-MY3) and Taiwan Protein Project (Grant No. AS-KPQ-105-TPP).
Publisher Copyright:
© 2018 by the authors.
PY - 2018/12/17
Y1 - 2018/12/17
N2 - Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.
AB - Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.
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U2 - 10.3390/ma11122572
DO - 10.3390/ma11122572
M3 - Article
AN - SCOPUS:85058666346
SN - 1996-1944
VL - 11
JO - Materials
JF - Materials
IS - 12
M1 - 2572
ER -