Characterization of iron core-gold shell nanoparticles for anti-cancer treatments: Chemical and structural transformations during storage and use

Ya Na Wu, Dar Bin Shieh, Li Xing Yang, Hwo Shuenn Sheu, Rongkun Zheng, Pall Thordarson, Dong Hwang Chen, Filip Braet

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.

原文English
文章編號2572
期刊Materials
11
發行號12
DOIs
出版狀態Published - 2018 12月 17

All Science Journal Classification (ASJC) codes

  • 一般材料科學
  • 凝聚態物理學

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