Characterization of iron core-gold shell nanoparticles for anti-cancer treatments: Chemical and structural transformations during storage and use

Ya Na Wu, Dar Bin Shieh, Li Xing Yang, Hwo Shuenn Sheu, Rongkun Zheng, Pall Thordarson, Dong Hwang Chen, Filip Braet

研究成果: Article

4 引文 (Scopus)

摘要

Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.

原文English
文章編號2572
期刊Materials
11
發行號12
DOIs
出版狀態Published - 2018 十二月 17

指紋

Oncology
Gold
Iron
Nanoparticles
Cells
Argon
Liquid nitrogen
X ray diffraction analysis
Aging of materials
Transmission electron microscopy
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

引用此文

Wu, Ya Na ; Shieh, Dar Bin ; Yang, Li Xing ; Sheu, Hwo Shuenn ; Zheng, Rongkun ; Thordarson, Pall ; Chen, Dong Hwang ; Braet, Filip. / Characterization of iron core-gold shell nanoparticles for anti-cancer treatments : Chemical and structural transformations during storage and use. 於: Materials. 2018 ; 卷 11, 編號 12.
@article{a0b4d546048c4ee58e8f72a31bf47707,
title = "Characterization of iron core-gold shell nanoparticles for anti-cancer treatments: Chemical and structural transformations during storage and use",
abstract = "Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or {"}ageing.{"} To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.",
author = "Wu, {Ya Na} and Shieh, {Dar Bin} and Yang, {Li Xing} and Sheu, {Hwo Shuenn} and Rongkun Zheng and Pall Thordarson and Chen, {Dong Hwang} and Filip Braet",
year = "2018",
month = "12",
day = "17",
doi = "10.3390/ma11122572",
language = "English",
volume = "11",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI AG",
number = "12",

}

Characterization of iron core-gold shell nanoparticles for anti-cancer treatments : Chemical and structural transformations during storage and use. / Wu, Ya Na; Shieh, Dar Bin; Yang, Li Xing; Sheu, Hwo Shuenn; Zheng, Rongkun; Thordarson, Pall; Chen, Dong Hwang; Braet, Filip.

於: Materials, 卷 11, 編號 12, 2572, 17.12.2018.

研究成果: Article

TY - JOUR

T1 - Characterization of iron core-gold shell nanoparticles for anti-cancer treatments

T2 - Chemical and structural transformations during storage and use

AU - Wu, Ya Na

AU - Shieh, Dar Bin

AU - Yang, Li Xing

AU - Sheu, Hwo Shuenn

AU - Zheng, Rongkun

AU - Thordarson, Pall

AU - Chen, Dong Hwang

AU - Braet, Filip

PY - 2018/12/17

Y1 - 2018/12/17

N2 - Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.

AB - Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and in vivo but were found to gradually lose that activity with storage or "ageing." To determine the reasons for this diminished anti-cancer activity, we examined Fe@Au nanoparticles at different preparation and storage stages by means of transmission electron microscopy combined with and energy-dispersive X-ray spectroscopy, along with X-ray diffraction analysis and cell viability tests. We found that dried and reconstituted Fe@Au nanoparticles, or Fe@Au nanoparticles within cells, decompose into irregular fragments of γ-F 2 O 3 and agglomerated gold clumps. These changes cause the loss of the particles' anti-cancer effects. However, we identified that the anti-cancer properties of Fe@Au nanoparticles can be well preserved under argon or, better still, liquid nitrogen storage for six months and at least one year, respectively.

UR - http://www.scopus.com/inward/record.url?scp=85058666346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058666346&partnerID=8YFLogxK

U2 - 10.3390/ma11122572

DO - 10.3390/ma11122572

M3 - Article

AN - SCOPUS:85058666346

VL - 11

JO - Materials

JF - Materials

SN - 1996-1944

IS - 12

M1 - 2572

ER -