Characterization of the epileptiform activity induced by magnesium-free solution in rat amygdala slices: An intracellular study

Po Wu Gean, Patricia Shinnick-Gallagher

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

The effect of Mg2+-free medium on neuronal activity in the basolateral nucleus of the rat amygdala slice was studied using intracellular recording techniques. Removal of Mg2+ from perfusate resulted in the development of three types of spontaneous activity, EPSP-like, ictal-like, and interictal-like events. The ictal-like events consisted of a long-duration depolarizing potential with several recurrent interictal bursts riding on it. The tonic and clonic firing phases seen in ictal-like events closely resembled the tonic and clonic phases of seizures which may provide a new model for studying the mechanisms underlying the generation of ictal seizures. The duration of interictal-like events induced in Mg2+-free solution is 10- to 30-fold longer than that produced by a convulsant. Two factors, a small or absent epileptiform afterhyperpolarization and a high density of NMDA receptor binding sites within the basolateral amygdala nucleus, may account for this difference.

原文English
頁(從 - 到)248-255
頁數8
期刊Experimental Neurology
101
發行號2
DOIs
出版狀態Published - 1988 八月

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

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