Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan

Ching Cherng Tzeng, Hsiao-Sheng Liu, Ching Li, Ying Tai Jin, Robert M. Chen, Wen-Horng Yang, Johny S. Lin

研究成果: Article

50 引文 (Scopus)

摘要

Established cancer cell lines with distinct characteristics are valuable in may aspects of in vitro study pertaining to tumor biology, as well as the possible geographic significance. Two long-term cell lines, BFTC905 and BFTC909, were established from primary transitional cell carcinomas (TCC) of patients from a blackfoot disease endemic area in Taiwan, where the prevalence and standard mortality rates of this cancer are unusually high. BFTC905 derived from a grade III TCC of urinary bladder has an epitheloid morphology, and BFTC909 derived from the sarcomatoid component of a grade III TCC of renal pelvis exhibits a fibroblastic growth pattern. They share similar morphological and immunocytochemical characteristics with the tumors of origin, have multiple chromosomal aberrations, and are tumorigenic in nude mice. BFTC905 reveals a unique homogeneously staining region at 11q13, the amplification of which has been detected in 20% of transitional cell carcinoma. In addition to the rarity of renal pelvic origin, the vimentin expression associated with an aggressive clinical behavior and a relatively high tumorigenicity as demonstrated by BFTC909 cells has also rarely been mentioned in TCC cell lines, but has been well documented in vivo and in vitro in renal cell carcinoma and breast cancer.

原文English
頁(從 - 到)1797-1804
頁數8
期刊Anticancer research
16
發行號4 A
出版狀態Published - 1996 七月 1

指紋

Urothelium
Endemic Diseases
Transitional Cell Carcinoma
Taiwan
Cell Line
Neoplasms
Renal Cell Carcinoma
Kidney Pelvis
Vimentin
Nude Mice
Chromosome Aberrations
Urinary Bladder
Staining and Labeling
Breast Neoplasms
Kidney
Mortality
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

Tzeng, C. C., Liu, H-S., Li, C., Jin, Y. T., Chen, R. M., Yang, W-H., & Lin, J. S. (1996). Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan. Anticancer research, 16(4 A), 1797-1804.
Tzeng, Ching Cherng ; Liu, Hsiao-Sheng ; Li, Ching ; Jin, Ying Tai ; Chen, Robert M. ; Yang, Wen-Horng ; Lin, Johny S. / Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan. 於: Anticancer research. 1996 ; 卷 16, 編號 4 A. 頁 1797-1804.
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abstract = "Established cancer cell lines with distinct characteristics are valuable in may aspects of in vitro study pertaining to tumor biology, as well as the possible geographic significance. Two long-term cell lines, BFTC905 and BFTC909, were established from primary transitional cell carcinomas (TCC) of patients from a blackfoot disease endemic area in Taiwan, where the prevalence and standard mortality rates of this cancer are unusually high. BFTC905 derived from a grade III TCC of urinary bladder has an epitheloid morphology, and BFTC909 derived from the sarcomatoid component of a grade III TCC of renal pelvis exhibits a fibroblastic growth pattern. They share similar morphological and immunocytochemical characteristics with the tumors of origin, have multiple chromosomal aberrations, and are tumorigenic in nude mice. BFTC905 reveals a unique homogeneously staining region at 11q13, the amplification of which has been detected in 20{\%} of transitional cell carcinoma. In addition to the rarity of renal pelvic origin, the vimentin expression associated with an aggressive clinical behavior and a relatively high tumorigenicity as demonstrated by BFTC909 cells has also rarely been mentioned in TCC cell lines, but has been well documented in vivo and in vitro in renal cell carcinoma and breast cancer.",
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Tzeng, CC, Liu, H-S, Li, C, Jin, YT, Chen, RM, Yang, W-H & Lin, JS 1996, 'Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan', Anticancer research, 卷 16, 編號 4 A, 頁 1797-1804.

Characterization of two urothelium cancer cell lines derived from a blackfoot disease endemic area in Taiwan. / Tzeng, Ching Cherng; Liu, Hsiao-Sheng; Li, Ching; Jin, Ying Tai; Chen, Robert M.; Yang, Wen-Horng; Lin, Johny S.

於: Anticancer research, 卷 16, 編號 4 A, 01.07.1996, p. 1797-1804.

研究成果: Article

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AU - Lin, Johny S.

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