Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Ping Chung Kuo; Hsin Yi Hung; Chi Wei Nian; Tsong Long Hwang; Ju Chien Cheng; Daih Huang Kuo; E. Jian Lee; Shih Huang Tai; Tian Shung Wu

doi:10.1021/acs.jnatprod.6b01141

Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Ping Chung Kuo, Hsin Yi Hung, Chi Wei Nian, Tsong Long Hwang, Ju Chien Cheng, Daih Huang Kuo, E. Jian Lee, Shih Huang Tai, Tian Shung Wu

研究成果: Article › 同行評審

40 引文斯高帕斯（Scopus）

摘要

Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC₅₀ values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.

原文	English
頁（從 - 到）	1055-1064
頁數	10
期刊	Journal of Natural Products
卷	80
發行號	4
DOIs	https://doi.org/10.1021/acs.jnatprod.6b01141
出版狀態	Published - 2017 4月 28

All Science Journal Classification (ASJC) codes

分析化學
分子醫學
藥理
藥學科學
藥物發現
補充和替代醫學
有機化學

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10.1021/acs.jnatprod.6b01141

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title = "Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa",

abstract = "Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC50 values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.",

author = "Kuo, {Ping Chung} and Hung, {Hsin Yi} and Nian, {Chi Wei} and Hwang, {Tsong Long} and Cheng, {Ju Chien} and Kuo, {Daih Huang} and Lee, {E. Jian} and Tai, {Shih Huang} and Wu, {Tian Shung}",

note = "Funding Information: This study was sponsored by the Ministry of Science and Technology, Taiwan, granted to T.-S.W. The authors are also thankful for partial financial support from Chang Gung Memorial Hospital (CMRPD1B0281-3, CMRPF1D0442-3, CMRPF 1F0011-3, CMRPF1F0061-3, and BMRP450 granted to H.-L.H.). Publisher Copyright: {\textcopyright} 2017 The American Chemical Society and American Society of Pharmacognosy.",

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doi = "10.1021/acs.jnatprod.6b01141",

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AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Nian, Chi Wei

AU - Hwang, Tsong Long

AU - Cheng, Ju Chien

AU - Kuo, Daih Huang

AU - Lee, E. Jian

AU - Tai, Shih Huang

AU - Wu, Tian Shung

N1 - Funding Information: This study was sponsored by the Ministry of Science and Technology, Taiwan, granted to T.-S.W. The authors are also thankful for partial financial support from Chang Gung Memorial Hospital (CMRPD1B0281-3, CMRPF1D0442-3, CMRPF 1F0011-3, CMRPF1F0061-3, and BMRP450 granted to H.-L.H.). Publisher Copyright: © 2017 The American Chemical Society and American Society of Pharmacognosy.

PY - 2017/4/28

Y1 - 2017/4/28

N2 - Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC50 values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.

AB - Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC50 values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.

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Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

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