Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin

Shih Huang Tai, Ping Chung Kuo, Sio Hong Lam, Shiow Chyn Huang, Yi Zhuan Kuo, Hsin Yi Hung, Meei Jen Liou, Po Chuen Shieh, E. Jian Lee, Tian Shung Wu

研究成果: Article

摘要

The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the 1H and 13C NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity.

原文English
頁(從 - 到)21616-21625
頁數10
期刊RSC Advances
9
發行號38
DOIs
出版狀態Published - 2019 一月 1

指紋

Acids
Bioactivity
Neurons
Medicine
Methanol
Nuclear magnetic resonance
Carbon
Glutamic Acid
cinnamophilin
dihydroguaiaretic acid

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

引用此文

Tai, Shih Huang ; Kuo, Ping Chung ; Lam, Sio Hong ; Huang, Shiow Chyn ; Kuo, Yi Zhuan ; Hung, Hsin Yi ; Liou, Meei Jen ; Shieh, Po Chuen ; Lee, E. Jian ; Wu, Tian Shung. / Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin. 於: RSC Advances. 2019 ; 卷 9, 編號 38. 頁 21616-21625.
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abstract = "The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the 1H and 13C NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity.",
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Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin. / Tai, Shih Huang; Kuo, Ping Chung; Lam, Sio Hong; Huang, Shiow Chyn; Kuo, Yi Zhuan; Hung, Hsin Yi; Liou, Meei Jen; Shieh, Po Chuen; Lee, E. Jian; Wu, Tian Shung.

於: RSC Advances, 卷 9, 編號 38, 01.01.2019, p. 21616-21625.

研究成果: Article

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AU - Lam, Sio Hong

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AU - Kuo, Yi Zhuan

AU - Hung, Hsin Yi

AU - Liou, Meei Jen

AU - Shieh, Po Chuen

AU - Lee, E. Jian

AU - Wu, Tian Shung

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N2 - The Machilus genus (Lauraceae) had been extensively utilized in folk medicine due to its broad range of bioactivities. In the present study, a series of chromatographic separations of the methanol extract of stems of M. philippinensis led to the identification of thirty eight compounds totally. Among these, biscinnamophilin (1), machilupins A-C (2-4), machilutone A (5), and machilusoxide A (6) were new compounds reported for the first time. In addition, 5 was characterized with a unprecedented carbon skeleton. Other known compounds, including the major compounds cinnamophilin (7) and meso-dihydroguaiaretic acid (8), are identified by comparison of their physical and spectroscopic data with reported values. One of the reported compounds, cinnamophilin A (10), should be revised as dehydroguaiaretic acid (9) after careful comparison of all the 1H and 13C NMR data. Moreover, the neuroprotective activity of cinnamophilin (7) was examined in a primary cortical neuron culture and the results indicated that 7 was effective against glutamate induced excitotoxicity.

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