Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam; Po Hsun Chen; Hsin Yi Hung; Tsong Long Hwang; Chih Chao Chiang; Tran Dinh Thang; Ping Chung Kuo; Tian Shung Wu

doi:10.3390/molecules23102541

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam, Po Hsun Chen, Hsin Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping Chung Kuo, Tian Shung Wu

研究成果: Article › 同行評審

27 引文斯高帕斯（Scopus）

摘要

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

原文	English
文章編號	2541
期刊	Molecules
卷	23
發行號	10
DOIs	https://doi.org/10.3390/molecules23102541
出版狀態	Published - 2018 10月 5

All Science Journal Classification (ASJC) codes

分析化學
化學（雜項）
分子醫學
藥學科學
藥物發現
物理與理論化學
有機化學

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10.3390/molecules23102541

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AU - Lam, Sio Hong

AU - Chen, Po Hsun

AU - Hung, Hsin Yi

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AU - Chiang, Chih Chao

AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2018/10/5

Y1 - 2018/10/5

N2 - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

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Chemical constituents from the stems of tinospora sinensis and their bioactivity

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