Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio-Hong Lam, Po Hsun Chen, Hsin-Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping-Chung Kuo, Tian-Shung Wu

研究成果: Article

摘要

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

原文English
文章編號2541
期刊Molecules
卷23
發行號10
DOIs
出版狀態Published - 2018 十月 5

指紋

Tinospora
N-Formylmethionine Leucyl-Phenylalanine
Lignans
Cytochalasin B
Pyrroles
alkaloids
phenylalanine
inorganic peroxides
Pancreatic Elastase
pyrroles
Bioactivity
stems
Alkaloids
Superoxides
Anti-Inflammatory Agents
anions
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

引用此文

Lam, S-H., Chen, P. H., Hung, H-Y., Hwang, T. L., Chiang, C. C., Thang, T. D., ... Wu, T-S. (2018). Chemical constituents from the stems of tinospora sinensis and their bioactivity. Molecules, 23(10), [2541]. https://doi.org/10.3390/molecules23102541
Lam, Sio-Hong ; Chen, Po Hsun ; Hung, Hsin-Yi ; Hwang, Tsong Long ; Chiang, Chih Chao ; Thang, Tran Dinh ; Kuo, Ping-Chung ; Wu, Tian-Shung. / Chemical constituents from the stems of tinospora sinensis and their bioactivity. 於: Molecules. 2018 ; 卷 23, 編號 10.
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Lam, S-H, Chen, PH, Hung, H-Y, Hwang, TL, Chiang, CC, Thang, TD, Kuo, P-C & Wu, T-S 2018, 'Chemical constituents from the stems of tinospora sinensis and their bioactivity', Molecules, 卷 23, 編號 10, 2541. https://doi.org/10.3390/molecules23102541

Chemical constituents from the stems of tinospora sinensis and their bioactivity. / Lam, Sio-Hong; Chen, Po Hsun; Hung, Hsin-Yi; Hwang, Tsong Long; Chiang, Chih Chao; Thang, Tran Dinh; Kuo, Ping-Chung; Wu, Tian-Shung.

於: Molecules, 卷 23, 編號 10, 2541, 05.10.2018.

研究成果: Article

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T1 - Chemical constituents from the stems of tinospora sinensis and their bioactivity

AU - Lam, Sio-Hong

AU - Chen, Po Hsun

AU - Hung, Hsin-Yi

AU - Hwang, Tsong Long

AU - Chiang, Chih Chao

AU - Thang, Tran Dinh

AU - Kuo, Ping-Chung

AU - Wu, Tian-Shung

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AB - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

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Lam S-H, Chen PH, Hung H-Y, Hwang TL, Chiang CC, Thang TD 等. Chemical constituents from the stems of tinospora sinensis and their bioactivity. Molecules. 2018 10月 5;23(10). 2541. https://doi.org/10.3390/molecules23102541

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