Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio-Hong Lam, Po Hsun Chen, Hsin-Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping-Chung Kuo, Tian-Shung Wu

研究成果: Article

摘要

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

原文English
文章編號2541
期刊Molecules
23
發行號10
DOIs
出版狀態Published - 2018 十月 5

指紋

Tinospora
N-Formylmethionine Leucyl-Phenylalanine
Lignans
Cytochalasin B
Pyrroles
alkaloids
phenylalanine
inorganic peroxides
Pancreatic Elastase
pyrroles
Bioactivity
stems
Alkaloids
Superoxides
Anti-Inflammatory Agents
anions
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

引用此文

Lam, Sio-Hong ; Chen, Po Hsun ; Hung, Hsin-Yi ; Hwang, Tsong Long ; Chiang, Chih Chao ; Thang, Tran Dinh ; Kuo, Ping-Chung ; Wu, Tian-Shung. / Chemical constituents from the stems of tinospora sinensis and their bioactivity. 於: Molecules. 2018 ; 卷 23, 編號 10.
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Chemical constituents from the stems of tinospora sinensis and their bioactivity. / Lam, Sio-Hong; Chen, Po Hsun; Hung, Hsin-Yi; Hwang, Tsong Long; Chiang, Chih Chao; Thang, Tran Dinh; Kuo, Ping-Chung; Wu, Tian-Shung.

於: Molecules, 卷 23, 編號 10, 2541, 05.10.2018.

研究成果: Article

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AU - Lam, Sio-Hong

AU - Chen, Po Hsun

AU - Hung, Hsin-Yi

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AU - Chiang, Chih Chao

AU - Thang, Tran Dinh

AU - Kuo, Ping-Chung

AU - Wu, Tian-Shung

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