Chemical Constituents of Hedyotis diffusa and Their Anti-Inflammatory Bioactivities

Hsin Yi Hung, Kun Ching Cheng, Ping Chung Kuo, I. Tsen Chen, Yue Chiun Li, Tsong Long Hwang, Sio Hong Lam, Tian Shung Wu

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)


Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among these isolates, selected compounds were examined for their anti-inflammatory activity. The results showed that rare substituted anthraquinones displayed potent inhibitory activity with IC50 values ranging from 0.15 ± 0.01 to 5.52 ± 1.59 µM on the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release cellular models. Meanwhile, the proposed drug target of the active anthraquinone was studied by computer modeling. The binding affinity between the anti-inflammatory anthraquinone and elastase was evaluated by molecular docking. These results provided the scientific insight into the medicinal values of Hedyotis diffusa and vision of development as lead compounds.

出版狀態Published - 2022 2月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 生理學
  • 分子生物學
  • 臨床生物化學
  • 細胞生物學


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