Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin, Tsong Long Hwang, Fu An Chen, Chia Hsin Huang, Hsin Yi Hung, Tian Shung Wu

研究成果: Article同行評審

36 引文 斯高帕斯(Scopus)

摘要

Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

原文English
頁(從 - 到)1911-1921
頁數11
期刊Journal of Natural Products
79
發行號8
DOIs
出版狀態Published - 2016 8月 26

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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