TY - JOUR
T1 - Chemical investigation on the root bark of Bombax malabarica
AU - Lam, Sio Hong
AU - Chen, Jhong Min
AU - Tsai, Sheng Fa
AU - Lee, Shoei Sheng
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology, Taiwan . Appendix A
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11
Y1 - 2019/11
N2 - Ten compounds were isolated from the root bark of Bombax malabarica, including two new compounds, bombamalin (1) and 3,4,5-trimethoxyphenol-1-[β-xylopyranosyl-(1 → 2)]-β-glucopyranoside (3), and shorealactone (4), a rare dehydroascorbic acid fused l-ε-viniferin. Compound 1 is an unusual bissesquiterpene, containing a 1,4-dioxene ring formed by fusing isohemigossypol with ent-cadinen-2-one. Their structures were elucidated by extensive spectroscopic analysis. This chemical reinvestigation is of value for chemotaxonomy of the Bombax genus, in particular the finding of the unusual 1 and rare 4. Among the isolates, shorealactone (4), l-epicatechin 5-O-β-D-xyloside (5), and 2-C-[β-D-apiosyl-(1 → 6)]- β-D-glucosyl]-1,3,6-trihydroxy-7-methoxyxanthone (6) displayed some inhibition against α-glucosidase with IC50 values of 224, 345, and 285 μM, respectively.
AB - Ten compounds were isolated from the root bark of Bombax malabarica, including two new compounds, bombamalin (1) and 3,4,5-trimethoxyphenol-1-[β-xylopyranosyl-(1 → 2)]-β-glucopyranoside (3), and shorealactone (4), a rare dehydroascorbic acid fused l-ε-viniferin. Compound 1 is an unusual bissesquiterpene, containing a 1,4-dioxene ring formed by fusing isohemigossypol with ent-cadinen-2-one. Their structures were elucidated by extensive spectroscopic analysis. This chemical reinvestigation is of value for chemotaxonomy of the Bombax genus, in particular the finding of the unusual 1 and rare 4. Among the isolates, shorealactone (4), l-epicatechin 5-O-β-D-xyloside (5), and 2-C-[β-D-apiosyl-(1 → 6)]- β-D-glucosyl]-1,3,6-trihydroxy-7-methoxyxanthone (6) displayed some inhibition against α-glucosidase with IC50 values of 224, 345, and 285 μM, respectively.
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U2 - 10.1016/j.fitote.2019.104376
DO - 10.1016/j.fitote.2019.104376
M3 - Article
C2 - 31629048
AN - SCOPUS:85073681069
SN - 0367-326X
VL - 139
JO - Fitoterapia
JF - Fitoterapia
M1 - 104376
ER -