Chemical Structure and Shape Enhance MR Imaging-Guided X-ray Therapy Following Marginative Delivery

Liu Chun Wang, Li Chan Chang, Guan Lin Su, Po Ya Chang, Hsiao Fen Hsu, Chin Lai Lee, Jie Ren Li, Min Chiao Liao, Suresh Thangudu, Jongjit Treekoon, Chun Chieh Yu, Hwo Shuenn Sheu, Ting Yuan Tu, Wen Pin Su, Chia Hao Su, Chen Sheng Yeh

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)


Ineffective site-specific delivery has seriously impeded the efficacy of nanoparticle-based drugs to a disease site. Here, we report the preparation of three different shapes (sphere, scroll, and oblate) to systematically evaluate the impact of the marginative delivery on the efficacy of magnetic resonance (MR) imaging-guided X-ray irradiation at a low dose of 1 Gy. In addition to the shape effect, the therapeutic efficacy is investigated for the first time to be strongly related to the structure effect that is associated with the chemical activity. The enhanced particle-vessel wall interaction of both the flat scroll and oblate following margination dynamics leads to greater accumulation in the lungs, resulting in superior performance over the sphere against lung tumor growth and suppression of lung metastasis. Furthermore, the impact of the structural discrepancy in nanoparticles on therapeutic efficacy is considered. The tetragonal oblate reveals that the feasibility of the charge-transfer process outperforms the orthorhombic scroll and cubic sphere to suppress tumors. Finally, surface area is also a crucial factor affecting the efficacy of X-ray treatments from the as-prepared particles.

頁(從 - 到)13056-13069
期刊ACS Applied Materials and Interfaces
出版狀態Published - 2022 3月 23

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)


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