@article{5d0982e654344bf7bd576520d23d70f9,
title = "Chemical Structure and Shape Enhance MR Imaging-Guided X-ray Therapy Following Marginative Delivery",
abstract = "Ineffective site-specific delivery has seriously impeded the efficacy of nanoparticle-based drugs to a disease site. Here, we report the preparation of three different shapes (sphere, scroll, and oblate) to systematically evaluate the impact of the marginative delivery on the efficacy of magnetic resonance (MR) imaging-guided X-ray irradiation at a low dose of 1 Gy. In addition to the shape effect, the therapeutic efficacy is investigated for the first time to be strongly related to the structure effect that is associated with the chemical activity. The enhanced particle-vessel wall interaction of both the flat scroll and oblate following margination dynamics leads to greater accumulation in the lungs, resulting in superior performance over the sphere against lung tumor growth and suppression of lung metastasis. Furthermore, the impact of the structural discrepancy in nanoparticles on therapeutic efficacy is considered. The tetragonal oblate reveals that the feasibility of the charge-transfer process outperforms the orthorhombic scroll and cubic sphere to suppress tumors. Finally, surface area is also a crucial factor affecting the efficacy of X-ray treatments from the as-prepared particles. ",
author = "Wang, {Liu Chun} and Chang, {Li Chan} and Su, {Guan Lin} and Chang, {Po Ya} and Hsu, {Hsiao Fen} and Lee, {Chin Lai} and Li, {Jie Ren} and Liao, {Min Chiao} and Suresh Thangudu and Jongjit Treekoon and Yu, {Chun Chieh} and Sheu, {Hwo Shuenn} and Tu, {Ting Yuan} and Su, {Wen Pin} and Su, {Chia Hao} and Yeh, {Chen Sheng}",
note = "Funding Information: C.-H.S. acknowledges financial support by the Ministry of Science and Technology, Taiwan (MOST109-2314-B-182A-011-MY3) and the Chang Gung Medical Foundation (CMRPG8I0141-3). W.-P.S. acknowledges financial support by the Ministry of Science and Technology, Taiwan (MOST 109-2314-B-006-078, 110-2314-B-006-108, 109-2314-B-006-084-MY3, and MOST 110-2321-B-006-005), funding from the National Cheng Kung University Hospital (NCKUH-11002002), and funding from E-DA hospital, grant number: NCKUEDA11005. T.-Y.T. is grateful for funding by the Ministry of Science and Technology (MOST), Taiwan, and the Young Scholar Program grant numbers MOST 109-2636-B-006-003- and 110-2636-B-006-013-. C.-S.Y. appreciates the financial support by the Ministry of Science and Technology, Taiwan (MOST109-2113-M-006-011-MY3). The authors thank Dr. Fong-Chia Lin, who offered the radiation facility for the colony assay. The authors are grateful for the support from the Core Research Laboratory, College of Medicine, the National Cheng Kung University, the Laboratory Animal Center, College of Medicine, the National Cheng Kung University, and the Core Facility of Taiwan Mouse Clinic and Animal Consortium. The authors are also grateful for the technical and equipment support provided by the Bioimaging Core Facility of the National Core Facility for Biopharmaceuticals, MOST, Taiwan, and the Center for Micro/Nano Science and Technology. This research was also supported in part by the Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. Additional financial support was provided by the Center of Applied Nanomedicine, National Cheng Kung University under the Featured Area Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. Funding Information: C.-H.S. acknowledges financial support by the Ministry of Science and Technology, Taiwan (MOST109-2314-B-182A-011-MY3) and the Chang Gung Medical Foundation (CMRPG8I0141-3). W.-P.S. acknowledges financial support by the Ministry of Science and Technology, Taiwan (MOST 109-2314-B-006-078, 110-2314-B-006-108, 109-2314-B-006-084-MY3 and MOST 110-2321-B-006-005), funding from the National Cheng Kung University Hospital (NCKUH-11002002), and funding from E-DA hospital grant number: NCKUEDA11005. T.-Y.T. is grateful for funding by the Ministry of Science and Technology (MOST), Taiwan, and the Young Scholar Program grant numbers MOST 109-2636-B-006-003- and 110-2636-B-006-013-. C.-S.Y. appreciates the financial support by the Ministry of Science and Technology, Taiwan (MOST109-2113-M-006-011-MY3). The authors thank Dr. Fong-Chia Lin, who offered the radiation facility for the colony assay. The authors are grateful for the support from the Core Research Laboratory, College of Medicine, the National Cheng Kung University the Laboratory Animal Center, College of Medicine, the National Cheng Kung University, and the Core Facility of Taiwan Mouse Clinic and Animal Consortium. The authors are also grateful for the technical and equipment support provided by the Bioimaging Core Facility of the National Core Facility for Biopharmaceuticals, MOST, Taiwan, and the Center for Micro/Nano Science and Technology. This research was also supported in part by the Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. Additional financial support was provided by the Center of Applied Nanomedicine, National Cheng Kung University under the Featured Area Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan. Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",
year = "2022",
month = mar,
day = "23",
doi = "10.1021/acsami.1c24991",
language = "English",
volume = "14",
pages = "13056--13069",
journal = "ACS Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "11",
}