Chemo- and enzymatic synthesis of partially and fully N-deacetylated 4-methylumbelliferyl chitobiosides: Fluorogenic substrates for chitinase

Yuji Honda, Shinji Tanimori, Mitsunori Kirihata, Satoshi Kaneko, Ken Tokuyasu, Masayuki Hashimoto, Takeshi Watanabe

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Partially and fully N-deacetylated 4-methylumberlliferyl chitobioside (1) derivatives, such as GlcN-GlcNAc-UMB (2), GlcNAc-GlcN-UMB (3), and (GlcN)2-UMB (4), were synthesized using chemo- and enzymatic procedure. Fluorescent aglycon was released from the chitobiosides 1, 2 and 3 by the action of chitinase. These UMB glycosides of heterochitobiose were versatile probes for the investigation of substrate binding chitinase from various sources. (C) 2000 Elsevier Science Ltd. All rights reserved.

原文English
頁(從 - 到)827-829
頁數3
期刊Bioorganic and Medicinal Chemistry Letters
10
發行號8
DOIs
出版狀態Published - 2000 4月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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