Chicoric acid is a potent anti-atherosclerotic ingredient by antioxidant action and anti-inflammation capacity

Kun Ling Tsai, Chung Lan Kao, Ching Hsia Hung, Yung Hsin Cheng, Huei Chen Lin, Pei Ming Chu

研究成果: Article

8 引文 (Scopus)

摘要

Atherosclerotic cardiovascular disease is linked to both oxidative stress and endothelial cell dysfunction. Chicoric acid has antioxidant and anti-inflammatory properties. In the present investigation, we demonstrated that chicoric acid inhibits oxidized low-density lipoprotein (oxLDL)-facilitated dysfunction in human umbilical vein endothelial cells (HUVECs). Oxidative injuries were tested by investigating the formation of intracellular reactive oxygen species (ROS) and by examining the activity of antioxidant enzymes and the function of endothelial nitric oxide synthase (eNOS). We also confirmed that chicoric acid mitigates apoptotic features caused by oxLDL, such as the subsequent break down of mitochondrial transmembrane potential and the activation of Bax, which promote DNA strand breaks and activate caspase-3. Moreover, our data revealed that chicoric acid attenuated the oxLDL activation of NF-κB, the attachment of THP-1 cells and the overexpression of adhesion molecules in human endothelial cells. The results of this study suggest a potential molecular mechanism through which chicoric acid inhibits oxLDL-induced human endothelial dysfunction.

原文English
頁(從 - 到)29600-29612
頁數13
期刊Oncotarget
8
發行號18
DOIs
出版狀態Published - 2017 一月 1

指紋

Antioxidants
Inflammation
Endothelial Cells
DNA Breaks
Nitric Oxide Synthase Type III
Human Umbilical Vein Endothelial Cells
Cell Adhesion Molecules
Caspase 3
Membrane Potentials
Reactive Oxygen Species
Oxidative Stress
Anti-Inflammatory Agents
Cardiovascular Diseases
chicoric acid
oxidized low density lipoprotein
Wounds and Injuries
Enzymes

All Science Journal Classification (ASJC) codes

  • Oncology

引用此文

Tsai, Kun Ling ; Kao, Chung Lan ; Hung, Ching Hsia ; Cheng, Yung Hsin ; Lin, Huei Chen ; Chu, Pei Ming. / Chicoric acid is a potent anti-atherosclerotic ingredient by antioxidant action and anti-inflammation capacity. 於: Oncotarget. 2017 ; 卷 8, 編號 18. 頁 29600-29612.
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Chicoric acid is a potent anti-atherosclerotic ingredient by antioxidant action and anti-inflammation capacity. / Tsai, Kun Ling; Kao, Chung Lan; Hung, Ching Hsia; Cheng, Yung Hsin; Lin, Huei Chen; Chu, Pei Ming.

於: Oncotarget, 卷 8, 編號 18, 01.01.2017, p. 29600-29612.

研究成果: Article

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