@article{900d714f037c407b8d8185aeac687c61,
title = "Childhood neglect is associated with corticostriatal circuit dysfunction in bipolar disorder adults",
abstract = "Bipolar disorder (BD) is characterized with cognitive impairment, which may be mediated by corticostriatal dysfunction. Here we examined whether history of childhood trauma, a risk factor for BD, was linked to corticostriatal dysfunction in BD patients. Furthermore, the possible associations between childhood trauma and cognitive impairment were examined. Thirty-eight BD participants who met the DSM-IV diagnostic criteria were enrolled. Childhood trauma was identified via the Childhood Trauma Questionnaire (CTQ). Participants completed the Wisconsin Card-Sorting Test (WCST). Resting-state functional magnetic resonance imaging (rsfMRI) was performed in participants using a 3T scanner. Bilateral caudate to whole-brain functional connectivity (FC) were analyzed, and childhood trauma was entered as a regressor of interest when controlling for age. Results showed the level of physical neglect was negatively correlated with left-caudate-seed FC to the frontoparietal network, including the right supramarginal gyrus, left inferior parietal lobule, right middle frontal gyrus, and right superior parietal lobule. The level of physical neglect was also negatively correlated with WCST performance. And the left-caudate-seed FCs to the frontoparietal network were positively correlated with WCST performance. Unequivocally, the specific impacts of physical neglect on brain connectivity and executive function in the BD population merit further investigation.",
author = "Hsieh, {Yi Ting} and Rebecca Wu and Tseng, {Huai Hsuan} and Wei, {Shyh Yuh} and Huang, {Ming Chyi} and Chang, {Hui Hua} and Yang, {Yen Kuang} and Chen, {Po See}",
note = "Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 107-2320-B-006-071, MOST 108-2320-B-006-047-MY3, MOST 108-2314-B-006-045, MOST 108-2320-B-006-004-, MOST 108-2321-B-006-026-MY2, and MOST 109-2628-B-006-004-) and National Cheng Kung University Hospital (NCKUH-10706020). The authors are indebted to the research participants. The authors wish to thank Chien Ting Lin for his administrative support. We thank the Mind Research and Imaging Center (MRIC) at National Cheng Kung University for consultation and instrument availability. The MRIC is supported by the Ministry of Science and Technology. Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 107-2320-B-006-071, MOST 108-2320-B-006-047-MY3, MOST 108-2314-B-006-045, MOST 108-2320-B-006-004-, MOST 108-2321-B-006-026-MY2, and MOST 109-2628-B-006-004-) and National Cheng Kung University Hospital ( NCKUH-10706020 ). The authors are indebted to the research participants. The authors wish to thank Chien Ting Lin for his administrative support. We thank the Mind Research and Imaging Center (MRIC) at National Cheng Kung University for consultation and instrument availability. The MRIC is supported by the Ministry of Science and Technology. Publisher Copyright: {\textcopyright} 2020",
year = "2021",
month = jan,
doi = "10.1016/j.psychres.2020.113550",
language = "English",
volume = "295",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
}