Chitosan oligosaccharides suppress nuclear factor-Kappa B activation and ameliorate experimental autoimmune uveoretinitis in mice

Sheng Min Hsu, Chang Hao Yang, Hsien Yang Tsai, Chia Jhen Lin, Yi Hsuan Fang, Chi Chang Shieh, Shun Hua Chen

研究成果: Article同行評審

摘要

We investigated the therapeutic potential and mechanism of chitosan oligosaccharides (COS) for experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid-binding protein (IRBP) peptides. At the same time, a high or low dose (20 or 10 mg/kg) of COS or phosphate-buffered saline (PBS) was given to mice daily after EAU induction. We found that mouse EAU is ameliorated by the high-dose COS treatment when compared with PBS treatment. In the retinas of high-dose COS-treated mice, the nuclear translocation of NF-κB subunit (p65) was suppressed, and the expression of several key EAU inflammatory mediators, IFN-γ, TNF-α, IL-1α, IL-4, IL-5, IL-6, IL-10, IL-17 and MCP-1 was lowered. These results suggest that COS may be a potential treatment for posterior uveitis.

原文English
文章編號8326
頁(從 - 到)1-11
頁數11
期刊International journal of molecular sciences
21
發行號21
DOIs
出版狀態Published - 2020 十一月 1

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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