Chlorpheniramine produces spinal motor, proprioceptive and nociceptive blockades in rats

Jann Inn Tzeng, Heng Teng Lin, Yu Wen Chen, Ching Hsia Hung, Jhi Joung Wang

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

This study aimed to assess the local anesthetic effects of chlorpheniramine in spinal anesthesia and is compared with mepivacaine, a widely-used local anesthetic. Spinal anesthesia with chlorpheniramine and mepivacaine was constructed in a dosage-dependent fashion after the rats were injected intrathecally. The spinal block effect of chlorpheniramine in motor function, nociception, and proprioception was compared to that of mepivacaine. We revealed that intrathecal chlorpheniramine and mepivacaine exhibited a dose-dependent spinal block of motor function, nociception, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potencies in motor function, nociception, and proprioception were chlorpheniramine>mepivacaine (P<0.01 for the differences). On the equianesthetic basis (ED25, ED50, ED75), the duration of spinal anesthesia with chlorpheniramine was greater than that of mepivacaine (P<0.01 for the differences). Instead of mepivacaine, chlorpheniramine produced a greater duration of sensory blockade than the motor blockade. These preclinical data showed that chlorpheniramine has a better sensory-selective action over motor block to produce more potent and long-lasting spinal anesthesia than mepivacaine.

原文English
頁(從 - 到)55-60
頁數6
期刊European Journal of Pharmacology
752
DOIs
出版狀態Published - 2015 4月 5

All Science Journal Classification (ASJC) codes

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