摘要
This study aimed to assess the local anesthetic effects of chlorpheniramine in spinal anesthesia and is compared with mepivacaine, a widely-used local anesthetic. Spinal anesthesia with chlorpheniramine and mepivacaine was constructed in a dosage-dependent fashion after the rats were injected intrathecally. The spinal block effect of chlorpheniramine in motor function, nociception, and proprioception was compared to that of mepivacaine. We revealed that intrathecal chlorpheniramine and mepivacaine exhibited a dose-dependent spinal block of motor function, nociception, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potencies in motor function, nociception, and proprioception were chlorpheniramine>mepivacaine (P<0.01 for the differences). On the equianesthetic basis (ED25, ED50, ED75), the duration of spinal anesthesia with chlorpheniramine was greater than that of mepivacaine (P<0.01 for the differences). Instead of mepivacaine, chlorpheniramine produced a greater duration of sensory blockade than the motor blockade. These preclinical data showed that chlorpheniramine has a better sensory-selective action over motor block to produce more potent and long-lasting spinal anesthesia than mepivacaine.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 55-60 |
| 頁數 | 6 |
| 期刊 | European Journal of Pharmacology |
| 卷 | 752 |
| DOIs | |
| 出版狀態 | Published - 2015 四月 5 |
指紋
All Science Journal Classification (ASJC) codes
- Pharmacology
引用此文
}
Chlorpheniramine produces spinal motor, proprioceptive and nociceptive blockades in rats. / Tzeng, Jann Inn; Lin, Heng Teng; Chen, Yu Wen; Hung, Ching Hsia; Wang, Jhi Joung.
於: European Journal of Pharmacology, 卷 752, 05.04.2015, p. 55-60.研究成果: Article
TY - JOUR
T1 - Chlorpheniramine produces spinal motor, proprioceptive and nociceptive blockades in rats
AU - Tzeng, Jann Inn
AU - Lin, Heng Teng
AU - Chen, Yu Wen
AU - Hung, Ching Hsia
AU - Wang, Jhi Joung
PY - 2015/4/5
Y1 - 2015/4/5
N2 - This study aimed to assess the local anesthetic effects of chlorpheniramine in spinal anesthesia and is compared with mepivacaine, a widely-used local anesthetic. Spinal anesthesia with chlorpheniramine and mepivacaine was constructed in a dosage-dependent fashion after the rats were injected intrathecally. The spinal block effect of chlorpheniramine in motor function, nociception, and proprioception was compared to that of mepivacaine. We revealed that intrathecal chlorpheniramine and mepivacaine exhibited a dose-dependent spinal block of motor function, nociception, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potencies in motor function, nociception, and proprioception were chlorpheniramine>mepivacaine (P<0.01 for the differences). On the equianesthetic basis (ED25, ED50, ED75), the duration of spinal anesthesia with chlorpheniramine was greater than that of mepivacaine (P<0.01 for the differences). Instead of mepivacaine, chlorpheniramine produced a greater duration of sensory blockade than the motor blockade. These preclinical data showed that chlorpheniramine has a better sensory-selective action over motor block to produce more potent and long-lasting spinal anesthesia than mepivacaine.
AB - This study aimed to assess the local anesthetic effects of chlorpheniramine in spinal anesthesia and is compared with mepivacaine, a widely-used local anesthetic. Spinal anesthesia with chlorpheniramine and mepivacaine was constructed in a dosage-dependent fashion after the rats were injected intrathecally. The spinal block effect of chlorpheniramine in motor function, nociception, and proprioception was compared to that of mepivacaine. We revealed that intrathecal chlorpheniramine and mepivacaine exhibited a dose-dependent spinal block of motor function, nociception, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potencies in motor function, nociception, and proprioception were chlorpheniramine>mepivacaine (P<0.01 for the differences). On the equianesthetic basis (ED25, ED50, ED75), the duration of spinal anesthesia with chlorpheniramine was greater than that of mepivacaine (P<0.01 for the differences). Instead of mepivacaine, chlorpheniramine produced a greater duration of sensory blockade than the motor blockade. These preclinical data showed that chlorpheniramine has a better sensory-selective action over motor block to produce more potent and long-lasting spinal anesthesia than mepivacaine.
UR - http://www.scopus.com/inward/record.url?scp=84923690599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923690599&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2015.02.006
DO - 10.1016/j.ejphar.2015.02.006
M3 - Article
C2 - 25697473
AN - SCOPUS:84923690599
VL - 752
SP - 55
EP - 60
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
ER -