Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic system

Yuan Chang Hsu, Hsiun Ing Chen, Yu Min Kuo, Lung Yu, Tung Yi Huang, Shean Jen Chen, Jih Ing Chuang, Fong Sen Wu, Chauying J. Jen

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE: The cardiovascular integration center not only sends out signals to offset the stimulus-induced responses but also resets the resting blood pressure. We hypothesize that GABAergic adaptations in the hypothalamus participate in the chronic exercise-induced cardiovascular resetting effects in conscious normotensive animals. METHODS: Male Wistar rats were subjected to chronic moderate exercise (CME, 8-week treadmill running at moderate intensity). A biotelemetry system was used to measure blood pressure, heart rate, autonomic nervous activities, baroreflex sensitivity and endogenous GABAergic activities in the paraventricular nucleus and the posterior hypothalamic area. Hypothalamic specimens were collected for quantifying GABA-related proteins and GABAergic neurons. RESULTS: CME reduced resting blood pressure, heart rate, sympathetic activity and enhanced parasympathetic activity and baroreflex sensitivity. Additionally, CME elevated the resting level of hypothalamic GABAergic activities, increased the percentage of GABAergic neurons in the hypothalamus and upregulated the hypothalamic protein levels of neuronal nitric oxide synthase, GAD67 and gephyrin, but not GABAA receptor. Moreover, a single bout of moderate exercise transiently elevated blood pressure and heart rate with prolonged high levels of neural controls (sympathetic activity, baroreflex sensitivity and hypothalamic GABAergic activities). CME accelerated the postexercise recovery in cardiovascular parameters and neural control alterations. CONCLUSION: Chronic treadmill running in normotensive rats augmented the GABAergic system in both paraventricular nucleus and posterior hypothalamic area, resulting in lower resting blood pressure, heart rate and sympathetic tone under conscious unrestraint conditions. This study provides insight into mechanisms important for explaining how chronic exercise resets the resting blood pressure.

原文English
頁(從 - 到)2339-2348
頁數10
期刊Journal of hypertension
29
發行號12
DOIs
出版狀態Published - 2011 12月

All Science Journal Classification (ASJC) codes

  • 內科學
  • 生理學
  • 心臟病學與心血管醫學

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