Chronological changes in genetic variance and heritability of systolic and diastolic blood pressure among chinese twin neonates

M. W. Yu, C. J. Chen, Chi-Jen Wang, S. L. Tong, M. Tien, T. Y. Lee, H. C. Lue, F. Y. Huang, C. C. Lan, K. H. Yang, H. C. Wang, H. Y. Shih, C. Y. Liu, J. S. Chen

研究成果: Article

9 引文 (Scopus)

摘要

In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.

原文English
頁(從 - 到)99-108
頁數10
期刊Acta Geneticae Medicae et Gemellologiae
39
發行號1
DOIs
出版狀態Published - 1990 一月 1

指紋

Newborn Infant
Blood Pressure
Dizygotic Twins
Placentation
Blood Pressure Monitors
Monozygotic Twins
Taiwan
Teaching Hospitals
General Hospitals
Gestational Age
Erythrocytes
Antigens

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

引用此文

Yu, M. W. ; Chen, C. J. ; Wang, Chi-Jen ; Tong, S. L. ; Tien, M. ; Lee, T. Y. ; Lue, H. C. ; Huang, F. Y. ; Lan, C. C. ; Yang, K. H. ; Wang, H. C. ; Shih, H. Y. ; Liu, C. Y. ; Chen, J. S. / Chronological changes in genetic variance and heritability of systolic and diastolic blood pressure among chinese twin neonates. 於: Acta Geneticae Medicae et Gemellologiae. 1990 ; 卷 39, 編號 1. 頁 99-108.
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abstract = "In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.",
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Yu, MW, Chen, CJ, Wang, C-J, Tong, SL, Tien, M, Lee, TY, Lue, HC, Huang, FY, Lan, CC, Yang, KH, Wang, HC, Shih, HY, Liu, CY & Chen, JS 1990, 'Chronological changes in genetic variance and heritability of systolic and diastolic blood pressure among chinese twin neonates', Acta Geneticae Medicae et Gemellologiae, 卷 39, 編號 1, 頁 99-108. https://doi.org/10.1017/S0001566000005614

Chronological changes in genetic variance and heritability of systolic and diastolic blood pressure among chinese twin neonates. / Yu, M. W.; Chen, C. J.; Wang, Chi-Jen; Tong, S. L.; Tien, M.; Lee, T. Y.; Lue, H. C.; Huang, F. Y.; Lan, C. C.; Yang, K. H.; Wang, H. C.; Shih, H. Y.; Liu, C. Y.; Chen, J. S.

於: Acta Geneticae Medicae et Gemellologiae, 卷 39, 編號 1, 01.01.1990, p. 99-108.

研究成果: Article

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T1 - Chronological changes in genetic variance and heritability of systolic and diastolic blood pressure among chinese twin neonates

AU - Yu, M. W.

AU - Chen, C. J.

AU - Wang, Chi-Jen

AU - Tong, S. L.

AU - Tien, M.

AU - Lee, T. Y.

AU - Lue, H. C.

AU - Huang, F. Y.

AU - Lan, C. C.

AU - Yang, K. H.

AU - Wang, H. C.

AU - Shih, H. Y.

AU - Liu, C. Y.

AU - Chen, J. S.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.

AB - In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.

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