摘要
Rationale: The contribution of bone marrow-borne hematopoietic cells to the ischemic myocardium has been documented. However, a pivotal study reported no evidence of myocardial regeneration from hematopoieticderived cells. The study did not take into account the possible effect of early injury-induced signaling as the test mice were parabiotically paired to partners immediately after surgery-induced myocardial injury when cross-circulation has not yet developed. Objective: To re-evaluate the role of circulating cells in the injured myocardium. Methods and Results: By combining pulse-chase labeling and parabiosis model, we show that circulating cells derived from the parabiont expressed cardiac-specific markers in the injured myocardium. Genetic fate mapping also revealed that circulating hematopoietic cells acquired cardiac cell fate by means of cell fusion and transdifferentiation. Conclusions: These results suggest that circulating cells participate in cardiomyocyte regeneration in a mouse model of parabiosis when the circulatory system is fully developed before surgery-induced heart injury.
原文 | English |
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頁(從 - 到) | 633-641 |
頁數 | 9 |
期刊 | Circulation Research |
卷 | 116 |
發行號 | 4 |
DOIs | |
出版狀態 | Published - 2015 2月 13 |
All Science Journal Classification (ASJC) codes
- 生理學
- 心臟病學與心血管醫學