Clinical and epidemiological characteristics in hospitalized young children with acute gastroenteritis in southern Taiwan: According to major pathogens

Taiwan Pediatric Infectious Disease Alliance

研究成果: Article

10 引文 (Scopus)

摘要

Background Acute gastroenteritis (AGE) can be caused by a wide array of pathogens, including bacteria, viruses, and parasites. A prospective study to investigate the epidemiology and clinical presentation in young children hospitalized with AGE was conducted in a medical center in southern Taiwan. Methods Patients aged less than 5 years who was hospitalized due to AGE in National Cheng Kung University Hospital were enrolled from July 2014 to June 2016. The demographic information, clinical features and laboratory data were collected by chart reviews, and stool samples were sent to Centers of Disease Control, Taiwan (Taiwan CDC) for a panel of pathogen identification consisting of two viruses, nine bacteria, and five parasites. Results Totally 441 patients were enrolled in this study. Salmonella spp. was the leading cause of disease (21.8%), followed by norovirus (17.0%), Clostridium difficile (9.5%), and rotavirus (9.3%). Norovirus identification rate was the highest among patients less than 6 months of age, while Salmonella was highest among patients between 2 and 3 years old. Patients with Salmonella infection frequently presented with fever, lethargy, bloody stool, and elevated serum level of C-reactive protein (CRP); norovirus and rotavirus infection frequently presented with vomiting. Salmonella gastroenteritis also resulted in longer hospitalization and more frequent antibiotics administration. C. difficile could be isolated from both gastroenteritis patients and control children. Conclusion Salmonella spp. was the most common pathogen of AGE in hospitalized children in southern Taiwan during 2014–2016, followed by norovirus and rotavirus. Further monitoring of epidemiology characteristics among cardinal pathogens of pediatric gastroenteritis is necessary.

原文English
頁(從 - 到)915-922
頁數8
期刊Journal of Microbiology, Immunology and Infection
50
發行號6
DOIs
出版狀態Published - 2017 十二月 1

指紋

Hospitalized Child
Gastroenteritis
Taiwan
Norovirus
Salmonella
Clostridium difficile
Rotavirus
Centers for Disease Control and Prevention (U.S.)
Parasites
Epidemiology
Viruses
Bacteria
Rotavirus Infections
Lethargy
Salmonella Infections
C-Reactive Protein
Vomiting
Hospitalization
Fever
Demography

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

引用此文

@article{6346f9e8810a48789205fed4bad7d45a,
title = "Clinical and epidemiological characteristics in hospitalized young children with acute gastroenteritis in southern Taiwan: According to major pathogens",
abstract = "Background Acute gastroenteritis (AGE) can be caused by a wide array of pathogens, including bacteria, viruses, and parasites. A prospective study to investigate the epidemiology and clinical presentation in young children hospitalized with AGE was conducted in a medical center in southern Taiwan. Methods Patients aged less than 5 years who was hospitalized due to AGE in National Cheng Kung University Hospital were enrolled from July 2014 to June 2016. The demographic information, clinical features and laboratory data were collected by chart reviews, and stool samples were sent to Centers of Disease Control, Taiwan (Taiwan CDC) for a panel of pathogen identification consisting of two viruses, nine bacteria, and five parasites. Results Totally 441 patients were enrolled in this study. Salmonella spp. was the leading cause of disease (21.8{\%}), followed by norovirus (17.0{\%}), Clostridium difficile (9.5{\%}), and rotavirus (9.3{\%}). Norovirus identification rate was the highest among patients less than 6 months of age, while Salmonella was highest among patients between 2 and 3 years old. Patients with Salmonella infection frequently presented with fever, lethargy, bloody stool, and elevated serum level of C-reactive protein (CRP); norovirus and rotavirus infection frequently presented with vomiting. Salmonella gastroenteritis also resulted in longer hospitalization and more frequent antibiotics administration. C. difficile could be isolated from both gastroenteritis patients and control children. Conclusion Salmonella spp. was the most common pathogen of AGE in hospitalized children in southern Taiwan during 2014–2016, followed by norovirus and rotavirus. Further monitoring of epidemiology characteristics among cardinal pathogens of pediatric gastroenteritis is necessary.",
author = "{Taiwan Pediatric Infectious Disease Alliance} and Ning Chung and Shih-Min Wang and Ching-Fen Shen and Kuo, {Fu Chun} and Tzong-Shiann Ho and Hsiung, {Chao Agnes} and Mu, {Jung Jung} and Wu, {Fang Tzy} and Huang, {Li Min} and Huang, {Yi Chuan} and Huang, {Yhu Chering} and Hsin Chi and Lin, {Hsiao Chuan} and Ching-Chuan Liu",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.jmii.2017.07.015",
language = "English",
volume = "50",
pages = "915--922",
journal = "Journal of Microbiology, Immunology and Infection",
issn = "1684-1182",
publisher = "Elsevier Taiwan LLC",
number = "6",

}

TY - JOUR

T1 - Clinical and epidemiological characteristics in hospitalized young children with acute gastroenteritis in southern Taiwan

T2 - According to major pathogens

AU - Taiwan Pediatric Infectious Disease Alliance

AU - Chung, Ning

AU - Wang, Shih-Min

AU - Shen, Ching-Fen

AU - Kuo, Fu Chun

AU - Ho, Tzong-Shiann

AU - Hsiung, Chao Agnes

AU - Mu, Jung Jung

AU - Wu, Fang Tzy

AU - Huang, Li Min

AU - Huang, Yi Chuan

AU - Huang, Yhu Chering

AU - Chi, Hsin

AU - Lin, Hsiao Chuan

AU - Liu, Ching-Chuan

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background Acute gastroenteritis (AGE) can be caused by a wide array of pathogens, including bacteria, viruses, and parasites. A prospective study to investigate the epidemiology and clinical presentation in young children hospitalized with AGE was conducted in a medical center in southern Taiwan. Methods Patients aged less than 5 years who was hospitalized due to AGE in National Cheng Kung University Hospital were enrolled from July 2014 to June 2016. The demographic information, clinical features and laboratory data were collected by chart reviews, and stool samples were sent to Centers of Disease Control, Taiwan (Taiwan CDC) for a panel of pathogen identification consisting of two viruses, nine bacteria, and five parasites. Results Totally 441 patients were enrolled in this study. Salmonella spp. was the leading cause of disease (21.8%), followed by norovirus (17.0%), Clostridium difficile (9.5%), and rotavirus (9.3%). Norovirus identification rate was the highest among patients less than 6 months of age, while Salmonella was highest among patients between 2 and 3 years old. Patients with Salmonella infection frequently presented with fever, lethargy, bloody stool, and elevated serum level of C-reactive protein (CRP); norovirus and rotavirus infection frequently presented with vomiting. Salmonella gastroenteritis also resulted in longer hospitalization and more frequent antibiotics administration. C. difficile could be isolated from both gastroenteritis patients and control children. Conclusion Salmonella spp. was the most common pathogen of AGE in hospitalized children in southern Taiwan during 2014–2016, followed by norovirus and rotavirus. Further monitoring of epidemiology characteristics among cardinal pathogens of pediatric gastroenteritis is necessary.

AB - Background Acute gastroenteritis (AGE) can be caused by a wide array of pathogens, including bacteria, viruses, and parasites. A prospective study to investigate the epidemiology and clinical presentation in young children hospitalized with AGE was conducted in a medical center in southern Taiwan. Methods Patients aged less than 5 years who was hospitalized due to AGE in National Cheng Kung University Hospital were enrolled from July 2014 to June 2016. The demographic information, clinical features and laboratory data were collected by chart reviews, and stool samples were sent to Centers of Disease Control, Taiwan (Taiwan CDC) for a panel of pathogen identification consisting of two viruses, nine bacteria, and five parasites. Results Totally 441 patients were enrolled in this study. Salmonella spp. was the leading cause of disease (21.8%), followed by norovirus (17.0%), Clostridium difficile (9.5%), and rotavirus (9.3%). Norovirus identification rate was the highest among patients less than 6 months of age, while Salmonella was highest among patients between 2 and 3 years old. Patients with Salmonella infection frequently presented with fever, lethargy, bloody stool, and elevated serum level of C-reactive protein (CRP); norovirus and rotavirus infection frequently presented with vomiting. Salmonella gastroenteritis also resulted in longer hospitalization and more frequent antibiotics administration. C. difficile could be isolated from both gastroenteritis patients and control children. Conclusion Salmonella spp. was the most common pathogen of AGE in hospitalized children in southern Taiwan during 2014–2016, followed by norovirus and rotavirus. Further monitoring of epidemiology characteristics among cardinal pathogens of pediatric gastroenteritis is necessary.

UR - http://www.scopus.com/inward/record.url?scp=85028636409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028636409&partnerID=8YFLogxK

U2 - 10.1016/j.jmii.2017.07.015

DO - 10.1016/j.jmii.2017.07.015

M3 - Article

C2 - 28882583

AN - SCOPUS:85028636409

VL - 50

SP - 915

EP - 922

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

SN - 1684-1182

IS - 6

ER -