Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis

Criselda Jean G. Cruz, Chao Chun Yang

研究成果: Short survey同行評審

1 引文 斯高帕斯(Scopus)

摘要

Psoriasis, a chronic, multisystemic inflammatory disease affecting millions of people globally, manifests as erythematous, thick, scaly plaques on the skin. Clinical evaluation remains to be the benchmark for diagnosis and monitoring of this debilitating disease. With current advancements in targeted molecular therapy for psoriasis such as biologics, molecular detection methods may also help guide clinical decisions and therapeutic strategies through quantification of circulating biomarkers, which could reflect the underlying pathogenic events happening at a certain point of the disease course. In this review, we will discuss how biomarkers are detected in serum samples using enzyme-linked immunosorbent assay (ELISA). This review will feature candidate biomarkers supported by clinical data for psoriasis including, but not limited to, cytokines, chemokines, adipokines, and antimicrobial peptides. A better understanding of the common method used for biomarker detection would enable physicians to interpret and correlate laboratory results with the disease pathogenesis and clinical outcomes, e.g., severity assessment and/or therapeutic response. With better health outcomes as the main goal, the utility of such information to evaluate and even predict treatment response would be a major step closer towards patient-tailored management.

原文English
文章編號1196323
期刊Frontiers in Molecular Biosciences
10
DOIs
出版狀態Published - 2023

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子生物學
  • 生物化學、遺傳與分子生物學(雜項)

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