Clinical characteristics of acute Q fever, scrub typhus, and murine typhus with delayed defervescence despite doxycycline treatment

Chung Hsu Lai, Chun Kai Huang, Hui Ching Weng, Hsing Chun Chung, Shiou Haur Liang, Jiun Nong Lin, Chih Wen Lin, Chuan Yuan Hsu, Hsi Hsun Lin

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

Doxycycline is the recommended antibiotic for acute Q fever, scrub typhus, and murine typhus and defervescence often occurs within 3 days of treatment. Patients with delayed defervescence (> 3 days) are troublesome for clinicians. To investigate the characteristics of such patients, 18 and 88 cases with and without delayed defervescence, respectively, were studied. By univariate analysis, absence of headache (P = 0.004), jaundice (P = 0.030), icteric sclera (P = 0.030), relative bradycardia (P = 0.003), and pulmonary involvement on chest x-ray (P = 0.028) were significant findings in patients with delayed defervescence. By multivariate analysis, absence of headache (odds ratio [OR] = 8.310; 95% confidence interval [CI] = 1.990-34.706, P = 0.004), jaundice (OR = 6.242; 95% CI = 1.374-28.365, P = 0.018), and relative bradycardia (OR = 10.449; 95% CI = 2.137-51.088, P = 0.004) were the independent characteristics of patients with delayed defervescence. In treating acute Q fever, scrub typhus, and murine typhus with doxycycline, clinicians should be aware that delayed defervescence may occur in patients presenting with jaundice, relative bradycardia, and absence of headache.

原文English
頁(從 - 到)441-446
頁數6
期刊American Journal of Tropical Medicine and Hygiene
79
發行號3
DOIs
出版狀態Published - 2008 9月

All Science Journal Classification (ASJC) codes

  • 寄生物學
  • 病毒學
  • 傳染性疾病

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