TY - JOUR
T1 - Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer
AU - Huang, Y. F.
AU - Shen, M. R.
AU - Hsu, K. F.
AU - Cheng, Y. M.
AU - Chou, C. Y.
N1 - Funding Information:
This work was partly supported by National Science Council, Taiwan (NSC93-2320-B-006-028 and NSC93-2314-B-006-020 to M-RS), National Health Research Institutes (NHRI-EX94-9311BS to M-RS and NHRI-EX94-9422BI to C-YC), Center for bioscience and biotechnology, National Cheng Kung University and Program for Promoting University Academic Excellence (91-B-FA09-1-4 to M-RS and C-YC). We thank Professor S-T Wang, Department of Public Health for the helpful discussion for data analysis.
PY - 2008/10/7
Y1 - 2008/10/7
N2 - This study was aimed to identify the expression and the correlation of insulin-like growth factor-1 (IGF-1) system and their prognostic impacts in cervical cancer. Seventy-two patients with early-stage cervical cancer were eligible. We obtained the serum levels of total IGF-1 and IGF binding protein-3 (IGFBP-3) by enzyme-linked immunosorbent assay and the expression of IGF-1 receptor (IGF-1R) in cancerous tissue by immuno-fluorescent (IF) stains. The 5-year recurrence-free and overall survival rates were significantly lower (P=0.003 and P=0.01, respectively) among patients with high-grade expression of tissue IGF-1R, compared with those with low-grade expression. After adjustment for other factors, preoperative serum total IGF-1 or IGFBP-3 levels failed to predict cancer death and recurrence. High-grade expression of IGF-1R and elevated preoperative squamous cell carcinoma antigen level were independent predictors of both death and recurrence, and combination of both factors could further help identify the subgroup of patients at higher death risk. The IF staining indicates the colocalisation of IGF-1 and IGF-1R in the cancerous tissues, whereas the IGF-1R expression is not correlated with circulating levels of IGF-1 or IGFBP-3. In early-stage cervical cancer, IGF-1 system may have a paracrine or autocrine function and the adverse impacts on prognosis by IGF-1R overexpression are implicated.
AB - This study was aimed to identify the expression and the correlation of insulin-like growth factor-1 (IGF-1) system and their prognostic impacts in cervical cancer. Seventy-two patients with early-stage cervical cancer were eligible. We obtained the serum levels of total IGF-1 and IGF binding protein-3 (IGFBP-3) by enzyme-linked immunosorbent assay and the expression of IGF-1 receptor (IGF-1R) in cancerous tissue by immuno-fluorescent (IF) stains. The 5-year recurrence-free and overall survival rates were significantly lower (P=0.003 and P=0.01, respectively) among patients with high-grade expression of tissue IGF-1R, compared with those with low-grade expression. After adjustment for other factors, preoperative serum total IGF-1 or IGFBP-3 levels failed to predict cancer death and recurrence. High-grade expression of IGF-1R and elevated preoperative squamous cell carcinoma antigen level were independent predictors of both death and recurrence, and combination of both factors could further help identify the subgroup of patients at higher death risk. The IF staining indicates the colocalisation of IGF-1 and IGF-1R in the cancerous tissues, whereas the IGF-1R expression is not correlated with circulating levels of IGF-1 or IGFBP-3. In early-stage cervical cancer, IGF-1 system may have a paracrine or autocrine function and the adverse impacts on prognosis by IGF-1R overexpression are implicated.
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U2 - 10.1038/sj.bjc.6604661
DO - 10.1038/sj.bjc.6604661
M3 - Article
C2 - 18781172
AN - SCOPUS:53049087091
SN - 0007-0920
VL - 99
SP - 1096
EP - 1102
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 7
ER -