Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications

Shih Min Wang, Ching Chuan Liu, Hui Wan Tseng, Jen Ren Wang, Chao Ching Huang, Yung Jung Chen, Yao Jong Yang, Shio Jean Lin, Tsu Fuh Yeh

研究成果: Article同行評審

281 引文 斯高帕斯(Scopus)

摘要

An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan in 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent of the patients were younger than age 5 years. Hand-foot-and-mouth syndrome occurred in 79% of the children and central nervous system (CNS) involvement in 35%, including nine fatal cases. The predominant neurological presentations were myoclonus (68%), vomiting (53%), and ataxia (35%). Brain stem encephalitis was the cardinal feature of EV71 CNS involvement during this outbreak. Magnetic resonance imaging and pathological findings illustrated that the midbrain, pons, and medulla were the target areas. EV71 brain stem encephalitis can present either with cerebellar signs and an initially mild, reversible course or with overwhelming neurogenic shock and neurogenic pulmonary edema (NPE) resulting in a fatal outcome. Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosis in this epidemic. Early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.

原文English
頁(從 - 到)184-190
頁數7
期刊Clinical Infectious Diseases
29
發行號1
DOIs
出版狀態Published - 1999

All Science Journal Classification (ASJC) codes

  • 微生物學(醫學)
  • 傳染性疾病

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