摘要
An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan in 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent of the patients were younger than age 5 years. Hand-foot-and-mouth syndrome occurred in 79% of the children and central nervous system (CNS) involvement in 35%, including nine fatal cases. The predominant neurological presentations were myoclonus (68%), vomiting (53%), and ataxia (35%). Brain stem encephalitis was the cardinal feature of EV71 CNS involvement during this outbreak. Magnetic resonance imaging and pathological findings illustrated that the midbrain, pons, and medulla were the target areas. EV71 brain stem encephalitis can present either with cerebellar signs and an initially mild, reversible course or with overwhelming neurogenic shock and neurogenic pulmonary edema (NPE) resulting in a fatal outcome. Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosis in this epidemic. Early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 184-190 |
| 頁數 | 7 |
| 期刊 | Clinical Infectious Diseases |
| 卷 | 29 |
| 發行號 | 1 |
| DOIs | |
| 出版狀態 | Published - 1999 一月 1 |
指紋
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
引用此文
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Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications. / Wang, Shih Min; Liu, Ching Chuan; Tseng, Hui Wan; Wang, Jen Ren; Huang, Chao Ching; Chen, Yung Jung; Yang, Yao Jong; Lin, Shio Jean; Yeh, Tsu Fuh.
於: Clinical Infectious Diseases, 卷 29, 編號 1, 01.01.1999, p. 184-190.研究成果: Article
TY - JOUR
T1 - Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications
AU - Wang, Shih Min
AU - Liu, Ching Chuan
AU - Tseng, Hui Wan
AU - Wang, Jen Ren
AU - Huang, Chao Ching
AU - Chen, Yung Jung
AU - Yang, Yao Jong
AU - Lin, Shio Jean
AU - Yeh, Tsu Fuh
PY - 1999/1/1
Y1 - 1999/1/1
N2 - An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan in 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent of the patients were younger than age 5 years. Hand-foot-and-mouth syndrome occurred in 79% of the children and central nervous system (CNS) involvement in 35%, including nine fatal cases. The predominant neurological presentations were myoclonus (68%), vomiting (53%), and ataxia (35%). Brain stem encephalitis was the cardinal feature of EV71 CNS involvement during this outbreak. Magnetic resonance imaging and pathological findings illustrated that the midbrain, pons, and medulla were the target areas. EV71 brain stem encephalitis can present either with cerebellar signs and an initially mild, reversible course or with overwhelming neurogenic shock and neurogenic pulmonary edema (NPE) resulting in a fatal outcome. Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosis in this epidemic. Early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.
AB - An outbreak of enterovirus 71 (EV71) infection occurred in Taiwan in 1998. The clinical spectrums and laboratory findings for 97 patients with virus culture-proven EV71 infections were analyzed. Eighty-seven percent of the patients were younger than age 5 years. Hand-foot-and-mouth syndrome occurred in 79% of the children and central nervous system (CNS) involvement in 35%, including nine fatal cases. The predominant neurological presentations were myoclonus (68%), vomiting (53%), and ataxia (35%). Brain stem encephalitis was the cardinal feature of EV71 CNS involvement during this outbreak. Magnetic resonance imaging and pathological findings illustrated that the midbrain, pons, and medulla were the target areas. EV71 brain stem encephalitis can present either with cerebellar signs and an initially mild, reversible course or with overwhelming neurogenic shock and neurogenic pulmonary edema (NPE) resulting in a fatal outcome. Brain stem encephalitis that progressed abruptly to neurogenic shock and NPE was indicative of poor prognosis in this epidemic. Early aggressive treatment and close monitoring of the neurological signs are mandatory to improve the chance of survival.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032766008&partnerID=8YFLogxK
U2 - 10.1086/520149
DO - 10.1086/520149
M3 - Article
C2 - 10433583
AN - SCOPUS:0032766008
VL - 29
SP - 184
EP - 190
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 1
ER -