@article{f4656e4ac92d41c99d762e21bfd147fd,
title = "Clinical ultrasound stimulating angiogenesis following drug-release from polymersomes on the ischemic zone for peripheral arterial occlusive disease",
abstract = "Peripheral Arterial Occlusive Disease (PAOD) is an aging disease that affects the quality of life of many people by its intermittent claudication and critical limb ischemia presentations. Traditional treatment and management of PAOD are asking patients to make a life change and medication with antiplatelet, statins and cilostazol, which decrease the possibility of clot formation. Our strategy has employed a magnetic Fe3O4-PLGA polymersome to carry the cilostazol into the ischemic area by magnetic attraction following remote-control drug release through low-energy ultrasound exposure. In the animal studies, the cilostazol-loaded Fe3O4-PLGA polymersomes were injected and accumulated at ischemic leg through magnetic attraction. Then, using a clinical-use ultrasound machine the leg was irradiated to forward cilostazol release from the accumulated polymersomes. Dramatically, we found an observable result of bloody flux recovery in the leg after 7 days compared to the non-treated leg that showed no evidence of the blood recovery.",
author = "Kan, {Chung Dann} and Wang, {Jieh Neng} and Li, {Wei Peng} and Lin, {Shao Hsien} and Chen, {Wei Ling} and Hsu, {Ya Ping} and Yeh, {Chen Sheng}",
note = "Funding Information: Acknowledgment: C.-S.Y., W.-P.L., and Y.-P.H. appreciate the support by the Ministry of Science and Technology ( MOST 105-2119-M-006-023-MY2 ), Taiwan. C.-D.K., J.-N.W., S.-H.L., and W.-L.C. appreciate the support by National Chung Kung University ( NCKUH-10705004 ) and the Ministry of Science and Technology ( MOST 106-2218-E-006-202 and MOST 105-2221-E-006-087-MY2 ), Taiwan. This work was supported by the Center of Applied Nanomedicine, National Cheng Kung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Funding Information: Acknowledgment: C.-S.Y., W.-P.L., and Y.-P.H. appreciate the support by the Ministry of Science and Technology (MOST 105-2119-M-006-023-MY2), Taiwan. C.-D.K., J.-N.W., S.-H.L., and W.-L.C. appreciate the support by National Chung Kung University (NCKUH-10705004) and the Ministry of Science and Technology (MOST 106-2218-E-006-202 and MOST 105-2221-E-006-087-MY2), Taiwan. This work was supported by the Center of Applied Nanomedicine, National Cheng Kung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = oct,
doi = "10.1016/j.nano.2018.07.010",
language = "English",
volume = "14",
pages = "2205--2213",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "7",
}