Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats

Ching Hsia Hung, Chong Chi Chiu, Kuo Sheng Liu, Jhi Joung Wang, Yu Wen Chen

研究成果: Article

7 引文 (Scopus)

摘要

Clonidine prolongs duration of analgesia when used as an adjunct to local anesthetics for infiltrative cutaneous analgesia, and propranolol produces local anesthesia. The purpose of the experiment was to evaluate clonidine as an adjuvant for propranolol on the quality and duration of cutaneous analgesia. A rat model of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick was employed to evaluate the cutaneous analgesic effect of propranolol combined with clonidine. The long-lasting local anesthetic bupivacaine was used as control. Cutaneous analgesia elicited by propranolol and bupivacaine was dose-dependent, and both propranolol (9.0 μmol) and bupivacaine (1.8 μmol) produced 100% nociceptive blockade. On an 50% effective dose (ED50) basis, the relative potency was bupivacaine [0.48 (0.42-0.55) μmol] greater than propranolol [2.27 (1.98-2.54) μmol] (p < 0.01). Subcutaneous saline and clonidine (0.12 μmol) did not produce cutaneous analgesia. The mixture of an ineffective-dose clonidine (0.12 μmol) and a drug (propranolol or bupivacaine) at ED50 or ED95 increased the potency and extended the duration at producing cutaneous analgesia. The resulting data demonstrated that propranolol is less potent than bupivacaine as an infiltrative anesthetic. Clonidine as an adjuvant for propranolol or bupivacaine has a significant peripheral action in increasing the depth and duration of action on infiltrative cutaneous analgesia.

原文English
頁(從 - 到)70-74
頁數5
期刊Neuroscience Letters
616
DOIs
出版狀態Published - 2016 三月 11

指紋

Clonidine
Propranolol
Analgesia
Bupivacaine
Skin
Local Anesthetics
Local Anesthesia
Reflex
Analgesics
Anesthetics
Muscles

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

引用此文

Hung, Ching Hsia ; Chiu, Chong Chi ; Liu, Kuo Sheng ; Wang, Jhi Joung ; Chen, Yu Wen. / Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats. 於: Neuroscience Letters. 2016 ; 卷 616. 頁 70-74.
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abstract = "Clonidine prolongs duration of analgesia when used as an adjunct to local anesthetics for infiltrative cutaneous analgesia, and propranolol produces local anesthesia. The purpose of the experiment was to evaluate clonidine as an adjuvant for propranolol on the quality and duration of cutaneous analgesia. A rat model of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick was employed to evaluate the cutaneous analgesic effect of propranolol combined with clonidine. The long-lasting local anesthetic bupivacaine was used as control. Cutaneous analgesia elicited by propranolol and bupivacaine was dose-dependent, and both propranolol (9.0 μmol) and bupivacaine (1.8 μmol) produced 100{\%} nociceptive blockade. On an 50{\%} effective dose (ED50) basis, the relative potency was bupivacaine [0.48 (0.42-0.55) μmol] greater than propranolol [2.27 (1.98-2.54) μmol] (p < 0.01). Subcutaneous saline and clonidine (0.12 μmol) did not produce cutaneous analgesia. The mixture of an ineffective-dose clonidine (0.12 μmol) and a drug (propranolol or bupivacaine) at ED50 or ED95 increased the potency and extended the duration at producing cutaneous analgesia. The resulting data demonstrated that propranolol is less potent than bupivacaine as an infiltrative anesthetic. Clonidine as an adjuvant for propranolol or bupivacaine has a significant peripheral action in increasing the depth and duration of action on infiltrative cutaneous analgesia.",
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Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats. / Hung, Ching Hsia; Chiu, Chong Chi; Liu, Kuo Sheng; Wang, Jhi Joung; Chen, Yu Wen.

於: Neuroscience Letters, 卷 616, 11.03.2016, p. 70-74.

研究成果: Article

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T1 - Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats

AU - Hung, Ching Hsia

AU - Chiu, Chong Chi

AU - Liu, Kuo Sheng

AU - Wang, Jhi Joung

AU - Chen, Yu Wen

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N2 - Clonidine prolongs duration of analgesia when used as an adjunct to local anesthetics for infiltrative cutaneous analgesia, and propranolol produces local anesthesia. The purpose of the experiment was to evaluate clonidine as an adjuvant for propranolol on the quality and duration of cutaneous analgesia. A rat model of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick was employed to evaluate the cutaneous analgesic effect of propranolol combined with clonidine. The long-lasting local anesthetic bupivacaine was used as control. Cutaneous analgesia elicited by propranolol and bupivacaine was dose-dependent, and both propranolol (9.0 μmol) and bupivacaine (1.8 μmol) produced 100% nociceptive blockade. On an 50% effective dose (ED50) basis, the relative potency was bupivacaine [0.48 (0.42-0.55) μmol] greater than propranolol [2.27 (1.98-2.54) μmol] (p < 0.01). Subcutaneous saline and clonidine (0.12 μmol) did not produce cutaneous analgesia. The mixture of an ineffective-dose clonidine (0.12 μmol) and a drug (propranolol or bupivacaine) at ED50 or ED95 increased the potency and extended the duration at producing cutaneous analgesia. The resulting data demonstrated that propranolol is less potent than bupivacaine as an infiltrative anesthetic. Clonidine as an adjuvant for propranolol or bupivacaine has a significant peripheral action in increasing the depth and duration of action on infiltrative cutaneous analgesia.

AB - Clonidine prolongs duration of analgesia when used as an adjunct to local anesthetics for infiltrative cutaneous analgesia, and propranolol produces local anesthesia. The purpose of the experiment was to evaluate clonidine as an adjuvant for propranolol on the quality and duration of cutaneous analgesia. A rat model of cutaneous trunci muscle reflex (CTMR) in response to local skin pinprick was employed to evaluate the cutaneous analgesic effect of propranolol combined with clonidine. The long-lasting local anesthetic bupivacaine was used as control. Cutaneous analgesia elicited by propranolol and bupivacaine was dose-dependent, and both propranolol (9.0 μmol) and bupivacaine (1.8 μmol) produced 100% nociceptive blockade. On an 50% effective dose (ED50) basis, the relative potency was bupivacaine [0.48 (0.42-0.55) μmol] greater than propranolol [2.27 (1.98-2.54) μmol] (p < 0.01). Subcutaneous saline and clonidine (0.12 μmol) did not produce cutaneous analgesia. The mixture of an ineffective-dose clonidine (0.12 μmol) and a drug (propranolol or bupivacaine) at ED50 or ED95 increased the potency and extended the duration at producing cutaneous analgesia. The resulting data demonstrated that propranolol is less potent than bupivacaine as an infiltrative anesthetic. Clonidine as an adjuvant for propranolol or bupivacaine has a significant peripheral action in increasing the depth and duration of action on infiltrative cutaneous analgesia.

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