Clostridium butyricum therapy for mild-moderate Clostridioides difficile infection and the impact of diabetes mellitus

Jen Chieh Lee, Chun Wei Chiu, Pei Jane Tsai, Ching Chi Lee, I. Hsiu Huang, Wen Chien Ko, Yuan Pin Hung

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

The therapeutic effect of Clostridium butyricum for adults with Clostridioides difficile infection (CDI) was investigated. A retrospective study was conducted in medical wards of Tainan Hospital, Ministry of Health and Welfare, between January 2013 and April 2020. The disease severity of CDI was scored based on the Clinical Practice Guidelines of the IDSA/SHEA. Treatment success was defined as the resolution of diarrhea within six days of a therapeutic intervention without the need to modify the therapeutic regimen. In total, 241 patients developed CDI during hospitalization in the study period. The treatment success rates for the 99 patients with mild-moderate CDI among them were as follows: metronidazole, 69.4%; C. butyricum, 68.2%; metronidazole plus C. butyricum, 66.7%; and oral vancomycin, 66.7% (p=1.00). Patients with treatment success were less likely to have diabetes mellitus than those with treatment failure (38.2% vs. 61.3%, p=0.05). Patients treated with C. butyricum alone or in combination with metronidazole had shorter durations of diarrhea than those treated with metronidazole alone (3.1 ± 2.0 days or 3.5 ± 2.4 days vs. 4.2 ± 3.5 days; p=0.43 or 0.71), although the differences were not statistically significant. In conclusion, the treatment success rate of C. butyricum alone or in combination with metronidazole for patients with CDI was non inferior to that of metronidazole alone. The presence of diabetes mellitus in affected individuals is a risk factor for treatment failure.

原文English
頁(從 - 到)37-44
頁數8
期刊Bioscience of Microbiota, Food and Health
41
發行號2
DOIs
出版狀態Published - 2022

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 微生物學
  • 免疫學
  • 應用微生物與生物技術
  • 消化內科

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