TY - JOUR
T1 - Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats
AU - Chen, Yu Wen
AU - Tzeng, Jann Inn
AU - Pan, He Jia
AU - Hung, Ching Hsia
AU - Chen, Yu Chung
AU - Wang, Jhi Joung
N1 - Funding Information:
The authors gratefully acknowledge the financial support provided by grants NSC 100-2314-B-039-017-MY3 and NSC 101-2314-B-006-037-MY3 from the National Science Council, Taiwan .
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/6/27
Y1 - 2014/6/27
N2 - The purpose of this study was to examine the effect of epinephrine as adjuvant for memantine or lidocaine as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we evaluated the effects of adding epinephrine to memantine or lidocaine on infiltrative cutaneous analgesia. Lidocaine, a known local anesthetic, was used as control. We found that epinephrine, memantine, and lidocaine produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potencies were epinephrine [0.012 (0.006-0.020)μmol]>memantine [4.010 (3.311-4.988)μmol]>lidocaine [6.177 (5.333-7.218)μmol] (P<0.05 for each comparison). Mixtures of epinephrine (2.7nmol or 13.7nmol) with drugs (memantine or lidocaine) at ED50 or ED95, respectively, enhanced the potency and prolonged the duration of action on infiltrative cutaneous analgesia. Intraperitoneal injection of co-administration of drugs (memantine or lidocaine) at ED95 with epinephrine (13.7nmol) produced no cutaneous analgesia (data not shown). Epinephrine, memantine, and lidocaine were shown to have local anesthetic effects as infiltrative cutaneous analgesia. Epinephrine increased the duration and potency of memantine and lidocaine as an infiltrative anesthetic.
AB - The purpose of this study was to examine the effect of epinephrine as adjuvant for memantine or lidocaine as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we evaluated the effects of adding epinephrine to memantine or lidocaine on infiltrative cutaneous analgesia. Lidocaine, a known local anesthetic, was used as control. We found that epinephrine, memantine, and lidocaine produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potencies were epinephrine [0.012 (0.006-0.020)μmol]>memantine [4.010 (3.311-4.988)μmol]>lidocaine [6.177 (5.333-7.218)μmol] (P<0.05 for each comparison). Mixtures of epinephrine (2.7nmol or 13.7nmol) with drugs (memantine or lidocaine) at ED50 or ED95, respectively, enhanced the potency and prolonged the duration of action on infiltrative cutaneous analgesia. Intraperitoneal injection of co-administration of drugs (memantine or lidocaine) at ED95 with epinephrine (13.7nmol) produced no cutaneous analgesia (data not shown). Epinephrine, memantine, and lidocaine were shown to have local anesthetic effects as infiltrative cutaneous analgesia. Epinephrine increased the duration and potency of memantine and lidocaine as an infiltrative anesthetic.
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U2 - 10.1016/j.neulet.2014.05.036
DO - 10.1016/j.neulet.2014.05.036
M3 - Article
C2 - 24861513
AN - SCOPUS:84901775767
VL - 574
SP - 59
EP - 63
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -