Coexposure of lead- and lipopolysaccharide-induced liver injury in rats: Involvement of nitric oxide-initiated oxidative stress and TNF-α

Ming-Yi Liu, Yu Jung Cheng, Cheng Kuang Chen, Bei-Chang Yang

研究成果: Article同行評審

32 引文 斯高帕斯(Scopus)

摘要

In this study, we investigated the interaction between lipopolysaccharide (LPS) and lead (Pb) and the involvement of tumor necrosis factor-α (TNF-α) and oxidative stress in Pb-plus-LPS (Pb/LPS)-induced liver damage in rats. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), TNF-α, nitric oxide (NO), and lipid peroxidation (LPO) were determined in rats treated with Pb and/or LPS. Pb ranging from 0 to 15 mg/kg dose dependently increased AST, ALT, NO, or LPO in LPS-treated rats. Pretreatment with iNOS inhibitor 1400W reduced NO, LPO, TNF-α, AST, and ALT in Pb/LPS-treated rats. Thus, Pb increased LPS-induced liver damage, which might be associated with increased NO-initiated oxidative stress and TNF-α in rats.

原文English
頁(從 - 到)360-364
頁數5
期刊Shock
23
發行號4
DOIs
出版狀態Published - 2005 四月 1

All Science Journal Classification (ASJC) codes

  • 急診醫學
  • 重症監護和重症監護醫學

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