Cognitive Effect of Transcranial Direct Current Stimulation on Left Dorsolateral Prefrontal Cortex in Mild Alzheimer's Disease: A Randomized, Double-Blind, Cross-Over Small-Scale Exploratory Study

Carol Sheei Meei Wang, Po See Chen, Tsung Yu Tsai, Nien Tsen Hou, Chia Hung Tang, Pai Lien Chen, Ying Che Huang, Kuo Sheng Cheng

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: Transcranial direct current stimulation (tDCS) is considered a potential therapeutic instrument for Alzheimer's disease (AD) because it affects long-term synaptic plasticity through the processes of long-term potentiation and long-term depression, thereby improving cognitive ability. Nevertheless, the efficacy of tDCS in treating AD is still debated. Dorsal lateral prefrontal cortex is the main role in executive functions. Objective: We investigate the cognitive effects of tDCS on AD patients. Methods: Thirty mild AD patients aged 66-86 years (mean=75.6) were included in a double-blind, randomized, sham-controlled crossover study. They were randomly assigned to receive 10 consecutive daily sessions of active tDCS (2mA for 30min) or a sham intervention and switched conditions 3 months later. The anodal and cathodal electrodes were placed on the left dorsal lateral prefrontal cortex and the right supraorbital area, respectively. Subjects underwent various neuropsychological assessments before and after the interventions. Results: The results showed that tDCS significantly improved Cognitive Abilities Screening Instrument scores, especially on the items of 'concentration and calculation', 'orientation', 'language ability', and 'categorical verbal fluency'. Mini-Mental State Examination and Wisconsin Card Sorting Test scores in all domains of 'concept formation', 'abstract thinking', 'cognitive flexibility', and 'accuracy' also improved significantly after tDCS. For the sham condition, no difference was found between the baseline scores and the after-intervention scores on any of the neuropsychological tests. Conclusion: >: Using tDCS improves the cognition of AD patients. Further large size clinical trials are necessary to validate the data.

原文English
頁(從 - 到)563-577
頁數15
期刊Journal of Alzheimer's Disease
98
發行號2
DOIs
出版狀態Published - 2024 3月 19

All Science Journal Classification (ASJC) codes

  • 一般神經科學
  • 臨床心理學
  • 老年病學和老年學
  • 精神病學和心理健康

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