TY - JOUR
T1 - Comparative pathogenicity of bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae
AU - Ko, W. C.
AU - Chiang, S. R.
AU - Yan, J. J.
AU - Chuang, Y. C.
N1 - Funding Information:
This study was supported by the grants from the National Science Council of the Republic of China (NSC 92-2314-B-006-060 and 92-2314-B-384-005).
PY - 2005/7
Y1 - 2005/7
N2 - Two bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae, Ah-2743 and Kp-129, respectively, were studied for their relative pathogenicity in comparison with Escherichia coli ATCC 25922. Ah-2743 caused significantly higher serum levels of tumour necrosis factor-α, interleukin (IL)-1β or IL-6 in human whole blood, and higher serum IL-1β and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. In addition, in BALB/c mice infected by intraperitoneal inoculation, Ah-2743 caused a higher fatality rate (80%) than did Kp-129 (0%). With intramuscular inoculation, Ah-2743 caused more rapid and intense local accumulation of inflammatory cells than did Kp-129, and myonecrosis was present only in Ah-2743-infected mice. These data indicate that Ah-2743 is more pathogenic than Kp-129 or E. coli ATCC 25922 for BALB/c mice. The cellular components or extracellular factors associated with increased cytokine induction and pathogenicity of A. hydrophila in mice merit further investigation.
AB - Two bacteraemic isolates of Aeromonas hydrophila and Klebsiella pneumoniae, Ah-2743 and Kp-129, respectively, were studied for their relative pathogenicity in comparison with Escherichia coli ATCC 25922. Ah-2743 caused significantly higher serum levels of tumour necrosis factor-α, interleukin (IL)-1β or IL-6 in human whole blood, and higher serum IL-1β and IL-6 levels in infected mice, than did Kp-129 and E. coli ATCC 25922. In addition, in BALB/c mice infected by intraperitoneal inoculation, Ah-2743 caused a higher fatality rate (80%) than did Kp-129 (0%). With intramuscular inoculation, Ah-2743 caused more rapid and intense local accumulation of inflammatory cells than did Kp-129, and myonecrosis was present only in Ah-2743-infected mice. These data indicate that Ah-2743 is more pathogenic than Kp-129 or E. coli ATCC 25922 for BALB/c mice. The cellular components or extracellular factors associated with increased cytokine induction and pathogenicity of A. hydrophila in mice merit further investigation.
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U2 - 10.1111/j.1469-0691.2005.01181.x
DO - 10.1111/j.1469-0691.2005.01181.x
M3 - Article
C2 - 15966973
AN - SCOPUS:21244473048
SN - 1198-743X
VL - 11
SP - 553
EP - 558
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 7
ER -