Comparison between botulinum toxin and corticosteroid injection in the treatment of acute and subacute tennis elbow: A prospective, randomized, double-blind, active drug-controlled pilot study

Yu-Ching Lin, Yuan Kun Tu, Sheng Shiung Chen, I. Ling Lin, Shih Ching Chen, How-Ran Guo

研究成果: Article

30 引文 (Scopus)

摘要

Objective: To compare botulinum toxin type A injection with corticosteroid injection in the treatment of tennis elbow. Design: In this prospective, randomized, double-blind, drug-controlled trial,19 affected elbows of 16 patients were randomly assigned to receive injection with botulinum toxin type A (Botox group) or triamcinolone acetonide (steroid group). We used the Visual Analog Scale, pain-free grip strength, and World Health Organization Quality of Life Brief Questionnaire to assess the perception of pain, grip strength, and quality of life, respectively. Measures were performed before and at 4, 8, and 12 wks after the treatment. Results: Four weeks after the treatment, the Botox group had smaller decrease in pain (P = 0.02) but greater decrease in grip strength (P = 0.01). The difference in grip strength remained significant at 8 wks (P = 0.03). No significant differences in quality of life were observed throughout the study period. Conclusions: Corticosteroid is superior to botulinum toxin type A in relieving pain in tennis elbow at 4 wks after injection. Because botulinum toxin injection did not relieve pain significantly but is associated with weakness, the muscle weakness caused by botulinum toxin is unlikely to be the sole mechanism of the pain relief observed in previous studies.

原文English
頁(從 - 到)653-659
頁數7
期刊American Journal of Physical Medicine and Rehabilitation
89
發行號8
DOIs
出版狀態Published - 2010 八月 1

指紋

Tennis Elbow
Botulinum Toxins
Hand Strength
Adrenal Cortex Hormones
Type A Botulinum Toxins
Injections
Pain
Pharmaceutical Preparations
Quality of Life
Therapeutics
Triamcinolone Acetonide
Pain Perception
Muscle Weakness
Elbow
Visual Analog Scale
Steroids

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)

引用此文

@article{6c8320c093ef43eebe08d288a9e6edb4,
title = "Comparison between botulinum toxin and corticosteroid injection in the treatment of acute and subacute tennis elbow: A prospective, randomized, double-blind, active drug-controlled pilot study",
abstract = "Objective: To compare botulinum toxin type A injection with corticosteroid injection in the treatment of tennis elbow. Design: In this prospective, randomized, double-blind, drug-controlled trial,19 affected elbows of 16 patients were randomly assigned to receive injection with botulinum toxin type A (Botox group) or triamcinolone acetonide (steroid group). We used the Visual Analog Scale, pain-free grip strength, and World Health Organization Quality of Life Brief Questionnaire to assess the perception of pain, grip strength, and quality of life, respectively. Measures were performed before and at 4, 8, and 12 wks after the treatment. Results: Four weeks after the treatment, the Botox group had smaller decrease in pain (P = 0.02) but greater decrease in grip strength (P = 0.01). The difference in grip strength remained significant at 8 wks (P = 0.03). No significant differences in quality of life were observed throughout the study period. Conclusions: Corticosteroid is superior to botulinum toxin type A in relieving pain in tennis elbow at 4 wks after injection. Because botulinum toxin injection did not relieve pain significantly but is associated with weakness, the muscle weakness caused by botulinum toxin is unlikely to be the sole mechanism of the pain relief observed in previous studies.",
author = "Yu-Ching Lin and Tu, {Yuan Kun} and Chen, {Sheng Shiung} and Lin, {I. Ling} and Chen, {Shih Ching} and How-Ran Guo",
year = "2010",
month = "8",
day = "1",
doi = "10.1097/PHM.0b013e3181cf564d",
language = "English",
volume = "89",
pages = "653--659",
journal = "American Journal of Physical Medicine and Rehabilitation",
issn = "0894-9115",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Comparison between botulinum toxin and corticosteroid injection in the treatment of acute and subacute tennis elbow

T2 - A prospective, randomized, double-blind, active drug-controlled pilot study

AU - Lin, Yu-Ching

AU - Tu, Yuan Kun

AU - Chen, Sheng Shiung

AU - Lin, I. Ling

AU - Chen, Shih Ching

AU - Guo, How-Ran

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Objective: To compare botulinum toxin type A injection with corticosteroid injection in the treatment of tennis elbow. Design: In this prospective, randomized, double-blind, drug-controlled trial,19 affected elbows of 16 patients were randomly assigned to receive injection with botulinum toxin type A (Botox group) or triamcinolone acetonide (steroid group). We used the Visual Analog Scale, pain-free grip strength, and World Health Organization Quality of Life Brief Questionnaire to assess the perception of pain, grip strength, and quality of life, respectively. Measures were performed before and at 4, 8, and 12 wks after the treatment. Results: Four weeks after the treatment, the Botox group had smaller decrease in pain (P = 0.02) but greater decrease in grip strength (P = 0.01). The difference in grip strength remained significant at 8 wks (P = 0.03). No significant differences in quality of life were observed throughout the study period. Conclusions: Corticosteroid is superior to botulinum toxin type A in relieving pain in tennis elbow at 4 wks after injection. Because botulinum toxin injection did not relieve pain significantly but is associated with weakness, the muscle weakness caused by botulinum toxin is unlikely to be the sole mechanism of the pain relief observed in previous studies.

AB - Objective: To compare botulinum toxin type A injection with corticosteroid injection in the treatment of tennis elbow. Design: In this prospective, randomized, double-blind, drug-controlled trial,19 affected elbows of 16 patients were randomly assigned to receive injection with botulinum toxin type A (Botox group) or triamcinolone acetonide (steroid group). We used the Visual Analog Scale, pain-free grip strength, and World Health Organization Quality of Life Brief Questionnaire to assess the perception of pain, grip strength, and quality of life, respectively. Measures were performed before and at 4, 8, and 12 wks after the treatment. Results: Four weeks after the treatment, the Botox group had smaller decrease in pain (P = 0.02) but greater decrease in grip strength (P = 0.01). The difference in grip strength remained significant at 8 wks (P = 0.03). No significant differences in quality of life were observed throughout the study period. Conclusions: Corticosteroid is superior to botulinum toxin type A in relieving pain in tennis elbow at 4 wks after injection. Because botulinum toxin injection did not relieve pain significantly but is associated with weakness, the muscle weakness caused by botulinum toxin is unlikely to be the sole mechanism of the pain relief observed in previous studies.

UR - http://www.scopus.com/inward/record.url?scp=77955046115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955046115&partnerID=8YFLogxK

U2 - 10.1097/PHM.0b013e3181cf564d

DO - 10.1097/PHM.0b013e3181cf564d

M3 - Article

C2 - 20134306

AN - SCOPUS:77955046115

VL - 89

SP - 653

EP - 659

JO - American Journal of Physical Medicine and Rehabilitation

JF - American Journal of Physical Medicine and Rehabilitation

SN - 0894-9115

IS - 8

ER -