Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine

Li Wei Cheng, Sheng Wen Huang, Li Min Huang, Luan Yin Chang, Pei Lan Shao, David Kiang, Jen Ren Wang

研究成果: Article

11 引文 斯高帕斯(Scopus)

摘要

Evaluation of the efficacy of influenza vaccines is essential for vaccine development. This study evaluated the neutralizing and hemagglutination-inhibition antibody response in subjects receiving the 2006-07 and 2007-08 seasonal influenza vaccines. ELISA-based microneutralization demonstrated a greater mean-fold increase and seroconversion rate than the hemagglutination-inhibition assay. The increase in the antibody titers against influenza H1 were higher than those against influenza H3 and influenza B, indicating that the H1 vaccine strain in the 2006-07 and 2007-08 seasons was more immunogenic. These data suggest that the neutralizing antibody response is a better measurement of influenza vaccine efficacy.

原文English
頁(從 - 到)43-49
頁數7
期刊Journal of Virological Methods
182
發行號1-2
DOIs
出版狀態Published - 2012 六月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Virology

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