Complex of simian virus large T antigen and p53 can bind DNA specifically

S. B. Long, H. Y. Ho, C. L. Chen, Ming-Derg Lai

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

The DNA-binding activity of p53 was suggested to be abrogated by binding of large T antigen. However we demonstrate that a function of p53 can form a complex with large T antigen and still bind DNA specifically. In EMSA analysis, both PAb 416 and 419 anti-large-T antibodies could induce supershift on p53-DNA complex using extracts derived from two T-antigen-transformed cell lines. In EMSA-Western analysis, one of the p53-complexes was shown to contain large T antigen.

原文English
頁(從 - 到)1375-1380
頁數6
期刊Anticancer research
15
發行號4
出版狀態Published - 1995 一月 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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