Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in pancreatic β-cells

Yi Wu, Show Ling Shyng, Pei Chun Chen

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Background: Leptin recruits KATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in KATP and Kv2.1 channel densities. Significance: Concerted KATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.

原文English
頁(從 - 到)29676-29690
頁數15
期刊Journal of Biological Chemistry
290
發行號50
DOIs
出版狀態Published - 2015 12月 11

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子生物學
  • 細胞生物學

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