Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Hsueh Yun Lee, Jang Yang Chang, Ling Yin Chang, Wen Yang Lai, Mei Jung Lai, Kuang Hsing Shih, Ching Chuan Kuo, Chi Yen Chang, Jing Ping Liou

研究成果: Article

19 引文 斯高帕斯(Scopus)

摘要

In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.

原文English
頁(從 - 到)3154-3157
頁數4
期刊Organic and Biomolecular Chemistry
9
發行號9
DOIs
出版狀態Published - 2011 五月 7

    指紋

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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