Constituents and anti-multidrug resistance activity of taiwanofungus camphoratus on human cervical cancer cells

Hsin Yi Hung, Chin Chuan Hung, Jun Weil Liang, Chin Fu Chen, Hung Yi Chen, Po Chuen Shieh, Ping Chung Kuo, Tian Shung Wu

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Resistance to anti-cancer drugs is one of the main factors of treatment failure resulting in high morbidity. Among the reasons of resistance, overexpression of efflux pumps leading to multidrug resistance is an important issue that needs to be solved. Taiwanofungus camphoratus has been used as a nutritional supplement to treat various cancers. However, its effects on the resistance to chemotherapeutic agents are still unknown. In this study, we report four new chemical constituents of T. camphoratus isolated from an ether extract: camphoratins K (1) and N (2) and benzocamphorins G (3) and I (4). Furthermore, we evaluated zhankuic acids A–C for their P-glycoprotein (P-gp) inhibitory effects. The results showed that zhankuic acid A was the most potent P-gp inhibitor compound and (at 20 µM) could reverse drug resistance in human cancer cells, restoring an IC50 of 78.5 nM for doxorubicin, of 48.5 nM for paclitaxel, and of 321.5 nM for vincristine, indicating a reversal fold of 48, 38, and 45 times, respectively. This study provides support for the use of T. camphoratus in the further development of cancer therapy.

原文English
文章編號3730
期刊Molecules
24
發行號20
DOIs
出版狀態Published - 2019 10月 16

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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