Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen, Ping-Chung Kuo, Shiow Chyn Huang, Tsong Long Hwang, Yu Yi Chan, Po Chuen Shieh, Nguyen Thi Ngan, Tran Dinh Thang, Tian-Shung Wu

研究成果: Article

11 引文 斯高帕斯(Scopus)

摘要

Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

原文English
頁(從 - 到)96-104
頁數9
期刊Journal of Natural Medicines
71
發行號1
DOIs
出版狀態Published - 2017 一月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

引用此

Shen, D. Y., Kuo, P-C., Huang, S. C., Hwang, T. L., Chan, Y. Y., Shieh, P. C., Ngan, N. T., Thang, T. D., & Wu, T-S. (2017). Constituents from the leaves of Clausena lansium and their anti-inflammatory activity. Journal of Natural Medicines, 71(1), 96-104. https://doi.org/10.1007/s11418-016-1033-x