Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen, Ping Chung Kuo, Shiow Chyn Huang, Tsong Long Hwang, Yu Yi Chan, Po Chuen Shieh, Nguyen Thi Ngan, Tran Dinh Thang, Tian Shung Wu

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)


Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

頁(從 - 到)96-104
期刊Journal of Natural Medicines
出版狀態Published - 2017 1月 1

All Science Journal Classification (ASJC) codes

  • 藥物發現
  • 補充和替代醫學
  • 藥學科學
  • 有機化學


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