TY - JOUR
T1 - Constituents from the stems of Aristolochia manshuriensis
AU - Wu, Pei Lin
AU - Su, Gwo Ching
AU - Wu, Tian-Shung
PY - 2003/7/1
Y1 - 2003/7/1
N2 - In a continuing search for bioactive compounds from Aristolochia species, 28 compounds, including three new constituents, demethylaristofolin E (1), aristomanoside (2), and dehydrooxoperezinone (3), were isolated from an extract of the stems of Aristolochia manshuriensis. The structures of these compounds were established by extensive 1D and 2D NMR spectral studies. Among these compounds, dehydrooxoperezinone (3) was found to inhibit the replication of HIV, with an EC50 value of 17.5 μg/mL and a therapeutic index of 1.43.
AB - In a continuing search for bioactive compounds from Aristolochia species, 28 compounds, including three new constituents, demethylaristofolin E (1), aristomanoside (2), and dehydrooxoperezinone (3), were isolated from an extract of the stems of Aristolochia manshuriensis. The structures of these compounds were established by extensive 1D and 2D NMR spectral studies. Among these compounds, dehydrooxoperezinone (3) was found to inhibit the replication of HIV, with an EC50 value of 17.5 μg/mL and a therapeutic index of 1.43.
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U2 - 10.1021/np0301238
DO - 10.1021/np0301238
M3 - Article
C2 - 12880323
AN - SCOPUS:0041842661
SN - 0163-3864
VL - 66
SP - 996
EP - 998
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 7
ER -