Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release

Yu Yi Chan, Tsong Long Hwang, Ping Chung Kuo, Hsin Yi Hung, Tian Shung Wu

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.

原文English
文章編號1454
期刊Molecules
22
發行號9
DOIs
出版狀態Published - 2017 9月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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