Constituents of Vittaria anguste-elongata and their biological activities

Pei Lin Wu, Yu Lin Hsu, Chen Wei Zao, Amooru G. Damu, Tian-Shung Wu

研究成果: Article同行評審

40 引文 斯高帕斯(Scopus)

摘要

Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant of Vittaria anguste-elongata. The structures of these compounds were determined by spectroscopic and chemical transformation methods. 5,7-Dihydroxy-3′, 4′,5′-trimethoxyflavone (18) displayed moderate cytotoxicity against human lung carcinoma and central nervous system carcinoma cell lines with inhibition of 89 and 61% at a concentration of 58 μM, respectively. Vittarilide-A (10) and -B (11) and ethyl 4-O-caffeoylquinate (14) exhibited moderate DPPH radical scavenging activity with IC50 values of 91, 290, and 234 μM, respectively.

原文English
頁(從 - 到)1180-1184
頁數5
期刊Journal of Natural Products
68
發行號8
DOIs
出版狀態Published - 2005 八月 1

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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