Constituents of Vittaria anguste-elongata and their biological activities

Pei Lin Wu, Yu Lin Hsu, Chen Wei Zao, Amooru G. Damu, Tian-Shung Wu

研究成果: Article

30 引文 (Scopus)

摘要

Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant of Vittaria anguste-elongata. The structures of these compounds were determined by spectroscopic and chemical transformation methods. 5,7-Dihydroxy-3′, 4′,5′-trimethoxyflavone (18) displayed moderate cytotoxicity against human lung carcinoma and central nervous system carcinoma cell lines with inhibition of 89 and 61% at a concentration of 58 μM, respectively. Vittarilide-A (10) and -B (11) and ethyl 4-O-caffeoylquinate (14) exhibited moderate DPPH radical scavenging activity with IC50 values of 91, 290, and 234 μM, respectively.

原文English
頁(從 - 到)1180-1184
頁數5
期刊Journal of Natural Products
68
發行號8
DOIs
出版狀態Published - 2005 八月 1

指紋

Scavenging
Neurology
Cytotoxicity
Bioactivity
Cells
Carcinoma
Acids
Inhibitory Concentration 50
Central Nervous System
Cell Line
Lung
compound 20

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

引用此文

Wu, P. L., Hsu, Y. L., Zao, C. W., Damu, A. G., & Wu, T-S. (2005). Constituents of Vittaria anguste-elongata and their biological activities. Journal of Natural Products, 68(8), 1180-1184. https://doi.org/10.1021/np050060o
Wu, Pei Lin ; Hsu, Yu Lin ; Zao, Chen Wei ; Damu, Amooru G. ; Wu, Tian-Shung. / Constituents of Vittaria anguste-elongata and their biological activities. 於: Journal of Natural Products. 2005 ; 卷 68, 編號 8. 頁 1180-1184.
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abstract = "Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant of Vittaria anguste-elongata. The structures of these compounds were determined by spectroscopic and chemical transformation methods. 5,7-Dihydroxy-3′, 4′,5′-trimethoxyflavone (18) displayed moderate cytotoxicity against human lung carcinoma and central nervous system carcinoma cell lines with inhibition of 89 and 61{\%} at a concentration of 58 μM, respectively. Vittarilide-A (10) and -B (11) and ethyl 4-O-caffeoylquinate (14) exhibited moderate DPPH radical scavenging activity with IC50 values of 91, 290, and 234 μM, respectively.",
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Wu, PL, Hsu, YL, Zao, CW, Damu, AG & Wu, T-S 2005, 'Constituents of Vittaria anguste-elongata and their biological activities', Journal of Natural Products, 卷 68, 編號 8, 頁 1180-1184. https://doi.org/10.1021/np050060o

Constituents of Vittaria anguste-elongata and their biological activities. / Wu, Pei Lin; Hsu, Yu Lin; Zao, Chen Wei; Damu, Amooru G.; Wu, Tian-Shung.

於: Journal of Natural Products, 卷 68, 編號 8, 01.08.2005, p. 1180-1184.

研究成果: Article

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