Contextualizing Genes by Using Text-Mined Co-Occurrence Features for Cancer Gene Panel Discovery

Hui O. Chen, Peng Chan Lin, Chen Ruei Liu, Chi Shiang Wang, Jung Hsien Chiang

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Developing a biomedical-explainable and validatable text mining pipeline can help in cancer gene panel discovery. We create a pipeline that can contextualize genes by using text-mined co-occurrence features. We apply Biomedical Natural Language Processing (BioNLP) techniques for literature mining in the cancer gene panel. A literature-derived 4,679 × 4,630 gene term-feature matrix was built. The EGFR L858R and T790M, and BRAF V600E genetic variants are important mutation term features in text mining and are frequently mutated in cancer. We validate the cancer gene panel by the mutational landscape of different cancer types. The cosine similarity of gene frequency between text mining and a statistical result from clinical sequencing data is 80.8%. In different machine learning models, the best accuracy for the prediction of two different gene panels, including MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets), and Oncomine cancer gene panel, is 0.959, and 0.989, respectively. The receiver operating characteristic (ROC) curve analysis confirmed that the neural net model has a better prediction performance (Area under the ROC curve (AUC) = 0.992). The use of text-mined co-occurrence features can contextualize each gene. We believe the approach is to evaluate several existing gene panels, and show that we can use part of the gene panel set to predict the remaining genes for cancer discovery.

原文English
文章編號771435
期刊Frontiers in Genetics
12
DOIs
出版狀態Published - 2021 10月 25

All Science Journal Classification (ASJC) codes

  • 分子醫學
  • 遺傳學
  • 遺傳學(臨床)

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